Publication Name	World Journal of Stem Cells
Manuscript ID	102280
Country	Austria

Category	Medicine, General & Internal
Manuscript Type	Editorial
Article Title	Protective activity of adipose-derived stem cell extracellular vesicles in ischemia and/or reperfusion
Manuscript Source	Invited Manuscript
All Author List	Alexander E Berezin
Funding Agency and Grant Number
Corresponding Author	Alexander E Berezin, MD, PhD, Professor, Internal Medicine-II, Paracelsus Medical University Salzburg, Mayakovsky av., 26, Salzburg 5020, Austria. aeberezin@gmail.com
Key Words	Extracellular vesicles; Adipose mesenchymal stem cells; MicroRNA-21-5p; Cardiac protection; Ischemia; Reperfusion
Core Tip	Extracellular vesicles, which are specifically derived from immunoregulatory cells such as mesenchymal stem cells or cardiac progenitor cells, have been shown to be important mediators of intercellular communication. They are ideally suited for cell-free regenerative cardiac therapy due to their low immunogenicity and high level of active molecule delivery safety. Extracellular vesicles derived from adipose-derived mesenchymal stem cell seem to show cardiac protective effects through their ability to deliver miR-21-5p acting via thioredoxin-interacting protein-thioredoxin complexes and subsequently to mediate anti-ischemic and antioxidant effects in ischemia and/or reperfusion injury.
Citation	<p>Berezin AE. Protective activity of adipose-derived stem cell extracellular vesicles in ischemia and/or reperfusion. <i>World J Stem Cells</i> 2025; 17(1): 102280</p>

Received	2024-10-13 15:10
Peer-Review Started	2024-10-13 15:11
To Make the First Decision
Return for Revision	2024-12-13 08:12
Revised	2024-12-15 19:52
Second Decision	2025-01-09 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-09 07:21
Articles in Press	2025-01-09 07:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-14 08:00

ISSN	1948-0210 (online)
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