Publication Name	World Journal of Transplantation
Manuscript ID	102384
Country	United States

Category	Transplantation
Manuscript Type	Retrospective Cohort Study
Article Title	Novel association between graft rejection and post-transplant malignancy in solid organ transplantation
Manuscript Source	Unsolicited Manuscript
All Author List	Hye Sung Kim, Wongi Woo, Young-Geun Choi, Ankit Bharat and Young Kwang Chae
Funding Agency and Grant Number
Corresponding Author	Young Kwang Chae, MD, Professor, Department of Medicine, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, 645 N. Michigan Avenue, Suite 1006, Chicago, IL 60611, United States. chaelabmeeting@gmail.com
Key Words	Graft rejection; Post-transplant malignancy; Transplantation; Transplant immunology; Immunosuppression; Kidney transplant; Liver transplant; Heart transplant; Lung transplant; Pancreas transplant
Core Tip	Our study uncovers a novel inverse relationship between rejection-induced graft failure (RGF) and post-transplant malignancy (PTM) in a cohort of 579905 solid organ transplant recipients. The findings suggest that immune activation during rejection enhances tumor surveillance and lowers malignancy risk, particularly in kidney transplants. In contrast, the immunosuppressive environment associated with PTM reduces the risk of RGF in all organs except the pancreas. These results underscore the need for tailored immunosuppressive strategies that balance the dual risks of rejection and malignancy to improve long-term outcomes in transplant recipients.
Citation	Kim HS, Woo W, Choi YG, Bharat A, Chae YK. Novel association between graft rejection and post-transplant malignancy in solid organ transplantation. World J Transplant 2025; In press

Received	2024-10-16 21:22
Peer-Review Started	2024-10-16 21:22
To Make the First Decision
Return for Revision	2024-12-02 02:39
Revised	2024-12-10 14:49
Second Decision	2025-01-09 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-09 09:47
Articles in Press	2025-01-09 09:47
Publication Fee Transferred	2024-12-18 02:15
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3230 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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