Publication Name	World Journal of Gastroenterology
Manuscript ID	102563
Country	China

Category	Medicine, General & Internal
Manuscript Type	Observational Study
Article Title	Helicobacter pylori infection is linked to metabolic dysfunction and associated steatotic liver disease: A large cross-sectional study
Manuscript Source	Unsolicited Manuscript
All Author List	Lin Ye, Kai Yan, Ze Tian, Zhi-Hua Xiao, Ru-Yi Xie, Zheng-Yuan Xie and Li Tao
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Research Program of Jiangxi Provincial Department of Education GJJ210225 2022 Provincial Health and Wellness Committee Science and Technology Program Projects 20221096 Jiangxi Provincial Natural Science Foundation's Young Scientists Fund 20242BAB20358
Corresponding Author	Li Tao, Department of Gastroenterology, the Second Affiliated Hospital of Nanchang University, 01 Minde Road, Nanchang City, Jiangxi Province, Postal Code 330008, China, Nanchang 330008, Jiangxi Province, China. ndefy17088@ncu.edu.cn
Key Words	Helicobacter pylori; Obesity; Blood glucose; Lipid profile; Blood pressure; Metabolic dysfunction-associated steatotic liver disease
Core Tip	This large cross-sectional study involving 28624 adults revealed that Helicobacter pylori (H. pylori) infection is correlated with metabolic disturbances, particularly in obese and older individuals. H. pylori-positive individuals exhibited elevated blood glucose, low-density lipoprotein cholesterol, and blood pressure levels, with worse metabolic profiles being observed in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). High blood glucose, body mass index, and diastolic pressure levels were identified as significant risk factors for H. pylori infection, whereas high-density lipoprotein was observed to be a protective factor. These findings suggest that H. pylori infection may contribute to metabolic disorders and MASLD progression, thereby offering insights for future research and prevention strategies.
Citation	<p>Ye L, Yan K, Tian Z, Xiao ZH, Xie RY, Xie ZY, Tao L. Helicobacter pylori infection is linked to metabolic dysfunction and associated steatotic liver disease: A large cross-sectional study. <i>World J Gastroenterol</i> 2025; 31(13): 102563</p>

Received	2024-10-22 02:41
Peer-Review Started	2024-10-22 02:41
To Make the First Decision
Return for Revision	2025-02-06 00:17
Revised	2025-02-19 18:31
Second Decision	2025-03-12 02:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-12 05:48
Articles in Press	2025-03-12 05:48
Publication Fee Transferred	2025-02-23 11:49
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-03-24 03:19

ISSN	1007-9327 (print) and 2219-2840 (online)
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