Publication Name	World Journal of Clinical Cases
Manuscript ID	102866
Country	China

Category	Infectious Diseases
Manuscript Type	Observational Study
Article Title	Correlations of vancomycin trough concentration and its efficacy and toxicity in intensive care unit patients
Manuscript Source	Unsolicited Manuscript
All Author List	Teng Guo, Li-Ying Du, Ming-Feng Liu, Xia-Jin Zhou and Xin-Ran Chen
Funding Agency and Grant Number	Funding Agency Grant Number Key Project Plan of Health and Medical Science Research in Hebei Provincial Health Commission No. 20190745
Corresponding Author	Xin-Ran Chen, Department of Pharmacy, The Fourth Hospital of Hebei Medical University, Hebei Key Laboratory of Clinical Pharmacy, No. 12 Jiankang Road, Chang’an District, Shijiazhuang 050011, Hebei Province, China. 48101847@hebmu.edu.cn
Key Words	Vancomycin; Therapeutic drug monitoring; Intensive care unit; Trough concentration; Methicillin-resistant Staphylococcus aureus infection; Area under the curve
Core Tip	Plasma concentration monitoring is essential for optimizing vancomycin therapy. This study investigates the relationship between clinical characteristics, pharmacokinetic parameters of vancomycin, especially the trough concentration and area under the curve, and its efficacy and nephrotoxicity in Chinese intensive care unit patients to inform personalized vancomycin administration. The results show that, the effective and safe concentration interval for vancomycin in intensive care unit patients is trough concentration 9.4-14.0 μg/mL.
Citation	Guo T, Du, LY, Liu MF, Zhou XJ, Chen XR. Correlations of vancomycin trough concentration and its efficacy and toxicity in intensive care unit patients. World J Clin Cases 2025; In press

Received	2024-11-04 05:44
Peer-Review Started	2024-11-04 05:45
To Make the First Decision
Return for Revision	2024-12-10 09:37
Revised	2024-12-24 03:45
Second Decision	2025-01-09 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-09 09:55
Articles in Press	2025-01-09 09:55
Publication Fee Transferred	2024-12-30 06:58
Edit the Manuscript by Language Editor	2025-01-16 00:05
Typeset the Manuscript

ISSN	2307-8960 (online)
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