Publication Name	World Journal of Experimental Medicine
Manuscript ID	103154
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Clinical Trials Study
Article Title	Plasma metabolomics analysis based on GC-MS in hypertensive patients with Yin deficiency and Yang hyperactivity syndrome
Manuscript Source	Unsolicited Manuscript
All Author List	Dinala Jialiken, Jing Dai, Ya-Dong Fan, Hai-Tao Zhang, Jin-Jun Shan, Wei-Chen Xu and Chong Zou
Funding Agency and Grant Number	Funding Agency Grant Number The Projects of Design and Statistics of Clinical Trials in Traditional Chinese Medicine A YXC2022-01-01 10 Exploring the Mechanism by which Pingyang Yuyin Granules Improve Hypertensive Kidney Injury Based on the 'Balance' Theory of PPARγ/HGF and TGF-β1/Smads Signaling Pathways Y2022ZR09 Jiangsu Funding Program for Excellent Postdoctoral Talent and Jiangsu graduate research and practice innovation program SJCX23_0906
Corresponding Author	Chong Zou, PhD, Professor, Department of Cardiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Qinhuai District, Nanjing 210004, Jiangsu Province, China. yfy105@njucm.edu.cn
Key Words	Hypertension; Metabolomics; GC-MS; YDYHS; Syndrome differentiation
Core Tip	Metabolomic profiling of hypertensive patients with Yin deficiency and Yang hyperactivity syndrome identified 20 potential biomarkers and four metabolic pathways. These biomarkers and pathways distinguished hypertensive patients with Yin deficiency and Yang hyperactivity syndrome from healthy controls. These potential biomarkers and pathways suggest the underlying metabolic basis of Yin deficiency and Yang hyperactivity syndrome in hypertensive patients. The metabolomic profiles provide novel insights into the mechanisms of Yin deficiency and Yang hyperactivity syndrome in hypertensive patients.
Citation	Jialiken D, Dai J, Fan YD, Zhang HT, Shan JJ, Xu WC, Zou C. Plasma metabolomics analysis based on GC-MS in hypertensive patients with Yin deficiency and Yang hyperactivity syndrome. World J Exp Med 2025; In press

Received	2024-11-11 09:59
Peer-Review Started	2024-11-11 09:59
To Make the First Decision
Return for Revision	2025-02-19 07:49
Revised	2025-02-28 05:39
Second Decision	2025-06-03 02:55
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-03 07:58
Articles in Press	2025-06-03 07:58
Publication Fee Transferred	2025-03-04 02:25
Edit the Manuscript by Language Editor	2025-06-04 08:37
Typeset the Manuscript

ISSN	2220-315x (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com