Publication Name	World Journal of Psychiatry
Manuscript ID	103185
Country	China

Category	Orthopedics
Manuscript Type	Retrospective Study
Article Title	Correlation of anxiety and depression with ankle function in chronic ankle instability patients and analysis of risk factors
Manuscript Source	Unsolicited Manuscript
All Author List	Zu-Po Yu
Funding Agency and Grant Number
Corresponding Author	Zu-Po Yu, Department of Orthopedics, The People’s Hospital of Pingyang and Pingyang Hospital Affiliated to Wenzhou Medical University and Pingyang Branch of Zhejiang Cancer Hospital, No. 555 Kun’ao Avenue, Kunyang Town, Pingyang County, Wenzhou 325400, Zhejiang Province, China. yuzupo123@163.com
Key Words	Risk factors; Correlation analysis; Ankle function; Anxiety and depression; Chronic ankle instability
Core Tip	The incidence of chronic ankle instability (CAI) reaches up to 53%, with nearly half of affected patients reporting negative emotions such as anxiety and depression. These psychological factors have negatively affected both treatment efficacy and functional recovery of the ankle. This study involved 116 patients with CAI and revealed that approximately 20.0% demonstrated varying severity of anxiety and depressive symptoms. Statistical analysis revealed a significant inverse correlation between the severity of patients’ anxiety/depression symptoms and their ankle functional outcomes. The study further determined three independent risk factors impairing ankle functional recovery: (1) Inadequate early functional exercise; (2) Increased pain levels as measured by the visual analog scale; and (3) Higher scores on the self-rating depression scale. These results indicate that clinical management should incorporate comprehensive psychological assessment and targeted interventions to optimize functional outcomes. Further, implementing early rehabilitation exercises and effective pain management strategies may help mitigate psychological distress while facilitating ankle function restoration.
Citation	Yu ZP. Correlation of anxiety and depression with ankle function in chronic ankle instability patients and analysis of risk factors. World J Psychiatry 2025; In press

Received	2025-03-21 09:49
Peer-Review Started	2025-03-21 09:53
To Make the First Decision
Return for Revision	2025-04-08 12:50
Revised	2025-04-20 07:31
Second Decision	2025-05-12 10:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-19 10:50
Articles in Press	2025-05-19 10:50
Publication Fee Transferred	2025-04-23 08:49
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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