Publication Name	World Journal of Clinical Cases
Manuscript ID	103239
Country	China

Category	Urology & Nephrology
Manuscript Type	Case Report
Article Title	Granulomatosis with polyangiitis induced by the anti-programmed cell death-1 inhibitor tislelizumab: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Jian-Hui Zhao, Jing-Jiao Wang and Yi-Wen Li
Funding Agency and Grant Number
Corresponding Author	Jian-Hui Zhao, Associate Chief Physician, MD, Department of Nephrology, Xinchang County People's Hospital, No. 117 Gushan Middle Road, Nanming Street, Xinchang 312500, Zhejiang Province, China. lyzhaojh@126.com
Key Words	Tislelizumab; Programmed cell death-1 inhibitor; Granulomatosis with polyangiitis; Anti-neutrophil cytoplasmic antibody-associated vasculitis; Case report
Core Tip	Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) due to immune checkpoint inhibitors is extremely rare. AAV caused by the programmed cell death-1 inhibitor, tislelizumab, has not been reported. Our patient developed AAV and granulomatosis with polyangiitis after tislelizumab treatment. Glucocorticoids given in combination with cyclophosphamide effectively treated our patient. However, after the patient discontinued treatment without authorization, the vasculitis recurred. The glucocorticoid + cyclophosphamide regimen was continued, but the patient’s renal function deteriorated.
Citation	Zhao JH, Wang JJ, Li YW. Granulomatosis with polyangiitis induced by the anti-programmed cell death-1 inhibitor tislelizumab: A case report. World J Clin Cases 2025; In press

Received	2024-11-13 09:39
Peer-Review Started	2024-11-13 09:39
To Make the First Decision
Return for Revision	2024-12-12 08:11
Revised	2024-12-19 08:47
Second Decision	2025-01-09 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-09 10:02
Articles in Press	2025-01-09 10:02
Publication Fee Transferred	2024-12-24 05:07
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-15 08:13

ISSN	2307-8960 (online)
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