Publication Name	World Journal of Experimental Medicine
Manuscript ID	103481
Country	Peru

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Immunomodulatory effect of allium sativum in type 2 diabetes mellitus
Manuscript Source	Invited Manuscript
All Author List	Elva Manuela Mejía Delgado, Juan Eduardo Quiroz-Aldave, María del Carmen Durand-Vásquez, Lea Noemí Aldave-Pita, Jenyfer María Fuentes-Mendoza, Luis Alberto Concepción-Urteaga, José Paz-Ibarra and Marcio José Concepción-Zavaleta
Funding Agency and Grant Number
Corresponding Author	Marcio José Concepción-Zavaleta, Carrera de Medicina Humana, Universidad Científica del Sur, 19 Panamericana Sur Km, Villa El Salvador, Lima 15067, Peru. mconcepcion@cientifica.edu.pe
Key Words	Garlic; Phytotherapy; Anti-inflammatory agents; Antioxidants; Immunomodulating agents; Type 2 diabetes mellitus
Core Tip	Allium sativum (garlic) demonstrates significant potential in managing type 2 diabetes mellitus through its immunomodulatory effects, primarily due to its organosulfur compounds like allicin. Preclinical and clinical studies suggest garlic improves metabolic control by reducing inflammation, oxidative stress, glucose levels, and insulin resistance, with benefits comparable to antidiabetic drugs. It may also positively impact complications such as metabolic-associated fatty liver disease, hypertension, nephropathy, and cardiovascular disease. However, more clinical trials are needed to confirm its therapeutic efficacy and optimize its use in type 2 diabetes mellitus treatment. Garlic offers promise as a natural adjunct to conventional diabetes management.
Citation	<p>Mejía Delgado EM, Quiroz-Aldave JE, Durand-Vásquez MDC, Aldave-Pita LN, Fuentes-Mendoza JM, Concepción-Urteaga LA, Paz-Ibarra J, Concepción-Zavaleta MJ. Immunomodulatory effect of allium sativum in type 2 diabetes mellitus. <i>World J Exp Med</i> 2025; 15(2): 103481</p>

Received	2024-11-21 11:50
Peer-Review Started	2024-11-25 01:01
To Make the First Decision
Return for Revision	2025-02-28 06:49
Revised	2025-03-10 05:06
Second Decision	2025-03-21 03:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-21 11:51
Articles in Press	2025-03-21 11:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-03-28 07:47

ISSN	2220-315x (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com