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Publication Name World Journal of Cardiology
Manuscript ID 103733
Country Saudi Arabia
Category Cardiac & Cardiovascular Systems
Manuscript Type Meta-Analysis
Article Title Combinatorial approach to treat iron overload cardiomyopathy in pediatric patients with thalassemia-major: A systematic review and meta-analysis
Manuscript Source Invited Manuscript
All Author List Moaz Safwan, Mariam Safwan Bourgleh, Aseel Alsudays and Khawaja Husnain Haider
Funding Agency and Grant Number
Corresponding Author Khawaja Husnain Haider, PhD, Professor, Department of Basic Sciences, Sulaiman Al Rajhi University, PO Box 777, Al Bukairiyah 51941, Saudi Arabia. khhaider@gmail.com
Key Words Amlodipine; Cardiomyopathy; Iron overload; Randomized controlled trials; Thalassemia
Core Tip Thalassemias are the most common inherited blood disorder caused by genetic mutations that significantly reduce or abolish normal hemoglobin production altogether. Iron chelation therapy, which aims to maintain safe iron levels, eliminate deposited iron, and promptly reverse the failing heart condition, is the current treatment for iron overload in thalassemia. Our systematic review and meta-analysis attempt to establish evidence from the reported randomized controlled trials that amlodipine can effectively alleviate cardiotoxicity related to iron overload in thalassemia major patients, especially when combined with iron chelators.
Citation Safwan M, Bourgleh MS, Alsudays A, Haider KH. Combinatorial approach to treat iron overload cardiomyopathy in pediatric patients with thalassemia-major: A systematic review and meta-analysis. World J Cardiol 2025; In press
Received
2024-11-29 09:24
Peer-Review Started
2024-12-02 00:23
To Make the First Decision
Return for Revision
2024-12-24 10:19
Revised
2025-01-05 18:53
Second Decision
2025-01-24 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-01-24 06:58
Articles in Press
2025-01-24 06:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
2025-01-25 19:39
Typeset the Manuscript
ISSN 1949-8462 (online)
Open Access Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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