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Articles in Press
1/24/2025 6:58:42 AM | Browse: 71 | Download: 0
Category |
Cardiac & Cardiovascular Systems |
Manuscript Type |
Meta-Analysis |
Article Title |
Combinatorial approach to treat iron overload cardiomyopathy in pediatric patients with thalassemia-major: A systematic review and meta-analysis
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Manuscript Source |
Invited Manuscript |
All Author List |
Moaz Safwan, Mariam Safwan Bourgleh, Aseel Alsudays and Khawaja Husnain Haider |
Funding Agency and Grant Number |
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Corresponding Author |
Khawaja Husnain Haider, PhD, Professor, Department of Basic Sciences, Sulaiman Al Rajhi University, PO Box 777, Al Bukairiyah 51941, Saudi Arabia. khhaider@gmail.com |
Key Words |
Amlodipine; Cardiomyopathy; Iron overload; Randomized controlled trials; Thalassemia |
Core Tip |
Thalassemias are the most common inherited blood disorder caused by genetic mutations that significantly reduce or abolish normal hemoglobin production altogether. Iron chelation therapy, which aims to maintain safe iron levels, eliminate deposited iron, and promptly reverse the failing heart condition, is the current treatment for iron overload in thalassemia. Our systematic review and meta-analysis attempt to establish evidence from the reported randomized controlled trials that amlodipine can effectively alleviate cardiotoxicity related to iron overload in thalassemia major patients, especially when combined with iron chelators. |
Citation |
Safwan M, Bourgleh MS, Alsudays A, Haider KH. Combinatorial approach to treat iron overload cardiomyopathy in pediatric patients with thalassemia-major: A systematic review and meta-analysis. World J Cardiol 2025; In press |
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Received |
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2024-11-29 09:24 |
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Peer-Review Started |
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2024-12-02 00:23 |
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To Make the First Decision |
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Return for Revision |
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2024-12-24 10:19 |
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Revised |
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2025-01-05 18:53 |
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Second Decision |
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2025-01-24 02:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-01-24 06:58 |
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Articles in Press |
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2025-01-24 06:58 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2025-01-25 19:39 |
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Typeset the Manuscript |
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ISSN |
1949-8462 (online) |
Open Access |
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
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