Publication Name	World Journal of Psychiatry
Manuscript ID	104221
Country	China

Category	Psychiatry
Manuscript Type	Randomized Controlled Trial
Article Title	Application and efficacy of quetiapine in patients with high-risk factors for bipolar disorder: A randomized controlled trial
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Lei Lei, Chen-Jie Ge, Hong Wang, Yu Fang, Lei Zeng, Shi-Liang Wang and Min-Cai Qian
Funding Agency and Grant Number	Funding Agency Grant Number Huzhou City Science and Technology Plan Public Welfare Technology Application Research Project [Key Project] 2020GZ42
Corresponding Author	Min-Cai Qian, Department of Neurosis and Psychosomatic Diseases, Huzhou Third Municipal Hospital, the Affiliated Hospital of Huzhou University, No. 2088 East Campsis Road, Huzhou 313000, Zhejiang Province, China. 13757289002@163.com
Key Words	Bipolar disorder; Anxiety disorders; Quetiapine; Comorbidity; Risk factor
Core Tip	This study evaluated the efficacy and safety of quetiapine combined with sertraline in patients with anxiety disorder (AD) and high-risk factors for bipolar disorder (BD). In a 24-week randomized trial involving 65 patients, those receiving combination therapy (Group B) showed significantly lower Hamilton anxiety scale scores than those on sertraline monotherapy (Group A) at weeks 1 and 24. Group B also demonstrated faster and sustained reductions in Hamilton depression scale and Bech-Rafaelsen Mania sale scores. Group B required less adjunctive zolpidem for insomnia, with no significant difference in adverse reactions between the groups. These findings support the use of quetiapine as an adjunctive treatment for managing complex AD at high-risk factors for BD, offering a safer and more effective strategy for high-risk patients.
Citation	Lei LL, Ge CJ, Wang H, Fang Y, Zeng L, Wang SL, Qian MC. Application and efficacy of quetiapine in patients with high-risk factors for bipolar disorder: A randomized controlled trial. World J Psychiatry 2025; In press

Received	2024-12-19 14:33
Peer-Review Started	2024-12-19 14:33
To Make the First Decision
Return for Revision	2025-03-19 08:50
Revised	2025-04-11 06:10
Second Decision	2025-06-09 02:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-16 11:45
Articles in Press	2025-06-16 11:45
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Typeset the Manuscript

ISSN	2220-3206 (online)
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