Publication Name	World Journal of Clinical Cases
Manuscript ID	104255
Country	China

Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	Mechanism of action of cuproptosis and prospects for anti-tumor therapy
Manuscript Source	Invited Manuscript
All Author List	Jie Xiao, Yan Wang and Xiao-Jun Yang
Funding Agency and Grant Number
Corresponding Author	Xiao-Jun Yang, Associate Professor, Chief Physician, MD, The First Clinical Medical School of Lanzhou University, Lanzhou University, No.199, Donggang West Road, Chengguan District, Lanzhou City, Gansu Province, China., Lanzhou 730000, Gansu Province, China. yangxjmd@aliyun.com
Key Words	Cuproptosis; Long non-coding RNAs; Colorectal cancer
Core Tip	This study reveals that copper ion-induced precipitation modifies mitochondrial proteins, promoting cell death. Low expression of the associated gene pyruvate dehydrogenase A1 is significantly correlated with improved overall survival in esophageal cancer patients. Tumor cells, characterized by disturbances in copper metabolism, display increased susceptibility to cuproptosis, eliciting diverse outcomes in distinct tumor types. Therefore, investigating the roles of cuproptosis-related genes and long non-coding RNAs in various tumors provides new directions for precision therapies targeting the cuproptosis pathway.
Citation	Xiao J, Wang Y, Yang XJ. Mechanism of action of cuproptosis and prospects for anti-tumor therapy. World J Clin Cases 2025; In press

Received	2024-12-23 12:15
Peer-Review Started	2024-12-23 12:15
To Make the First Decision
Return for Revision	2025-03-12 06:49
Revised	2025-03-24 03:43
Second Decision	2025-05-09 02:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-10 00:59
Articles in Press	2025-05-10 00:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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