Publication Name	World Journal of Diabetes
Manuscript ID	104409
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Letter to the Editor
Article Title	L-arginine overdose is a potential risk factor for myocardial injury in patients with type 2 diabetes
Manuscript Source	Invited Manuscript
All Author List	Yan Chen, Meng-Ting Dai and Guo-Hua Gong
Funding Agency and Grant Number	Funding Agency Grant Number The Medical Health Science and Technology Project of Zhejiang Provincial Health Commission 2024KY138 The Basic Research Project of Wenzhou Municipal Science and Technology Bureau Y20240008 The Key Discipline of Zhejiang Province in Medical Technology (First Class, Category A) The Key Laboratory of School of Laboratory Medicine and Life Sciences, Wenzhou Medical University of China JS2023003
Corresponding Author	Guo-Hua Gong, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, No. 82 West College Road, Wenzhou 325035, Zhejiang Province, China. guohgong@wmu.edu.cn
Key Words	L-arginine; Glucose; Oxidative stress; Antioxidant; Inflamation; Caridac
Core Tip	The effect of L-arginine (L-Arg) daily administration is dependent on its concentration in type II diabetes. Low L-Arg is safe and good for diabetes. However, over 0.5 g/kg L-Arg is a risk factor for the heart. It may aggravate myocardial damage by increasing blood glucose levels, oxidative stress, inflammatory mediator levels, and cardiac remodeling.
Citation	Chen Y, Dai MT, Gong GH. L-arginine overdose is a potential risk factor for myocardial injury in patients with type 2 diabetes. World J Diabetes 2025; In press

Received	2025-01-06 03:44
Peer-Review Started	2025-01-07 01:03
To Make the First Decision
Return for Revision	2025-02-13 02:47
Revised	2025-02-24 10:55
Second Decision	2025-03-12 02:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-12 06:37
Articles in Press	2025-03-12 06:37
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-03-13 12:02
Typeset the Manuscript

ISSN	1948-9358 (online)
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