Publication Name	World Journal of Clinical Cases
Manuscript ID	104421
Country	China

Category	Infectious Diseases
Manuscript Type	Case Report
Article Title	Hepatitis B virus and hepatitis D virus co-infection complicated by autoimmune hepatitis: Two case reports
Manuscript Source	Unsolicited Manuscript
All Author List	Jing Dou, Xin-Yan Zhao, Zhuan-Guo Wang, Zhong-Hui Ning, Xiao-Zhong Wang and Feng Guo
Funding Agency and Grant Number	Funding Agency Grant Number Xinjiang “Tianshan Talents” Medical and Health High-Level Talent Training Program-Young and Middle-Aged Backbone Medical Talents
Corresponding Author	Feng Guo, Professor, Department of Hepatology, Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University, No. 116 Huanghe Road, Shayibak District, Urumqi 830000, Xinjiang Uygur Autonomous Region, China. gf_sj@163.com
Key Words	Hepatitis D virus; Hepatitis B virus; Autoimmune hepatitis; Liver biopsy; Pathology; Case report
Core Tip	This study reports, for the first time, two patients with hepatitis D virus (HDV)-hepatitis B virus co-infection combined with autoimmune hepatitis (AIH) who were not treated with interferon and achieved serological conversion and histological remission with antiviral drugs (entecavir/tenofovir alafenamide) in combination with immunosuppression (prednisone + azathioprine). Patients with severe HDV-related liver disease should be routinely screened for autoantibodies to avoid exacerbation by interferon therapy. The combination therapy was effective in controlling HDV-hepatitis B virus co-infection associated AIH, suggesting that aberrant immunoregulation may be an important mechanism of HDV-induced AIH, providing new evidence for elucidating the pathogenesis of this complex disease, and emphasizing the necessity of immune mechanism research.
Citation	Dou J, Zhao XY, Wang ZG, Ning ZH, Wang XZ, Guo F. Hepatitis B virus and hepatitis D virus co-infection complicated by autoimmune hepatitis: Two case reports. World J Clin Cases 2025; In press

Received	2024-12-19 10:18
Peer-Review Started	2024-12-20 01:42
To Make the First Decision
Return for Revision	2025-03-19 02:14
Revised	2025-04-02 07:35
Second Decision	2025-05-28 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-28 10:18
Articles in Press	2025-05-28 10:18
Publication Fee Transferred	2025-04-23 15:12
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Typeset the Manuscript

ISSN	2307-8960 (online)
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