| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
miR-10a-5p and miR-10b-5p restore colonic motility in aged mice
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Gain Baek, Rajan Singh, Se Eun Ha, Hayeong Cho, Sesh Padmanabhan, Vachan Vishwanath, Min Seob Kim, Dahyun Seon, Jisong You, Moon Young Lee and Seungil Ro |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Research Foundation of Korea Grant Funded by the Korean Government (MSIT) |
NRF-2021R1C1C2006743 and NRF-2021R1A2C1095311 |
| National Institutes of Health Grants |
R01DK103055 |
| RosVivo Therapeutics |
AWD-01-00003158 |
|
| Corresponding Author |
Seungil Ro, PhD, Professor, Department of Physiology and Cell Biology, University of Nevada School of Medicine, Building L-207E, 1664 North Virginia Street, Reno, NV 89557, United States. sro@med.unr.edu |
| Key Words |
MicroRNAs; Aged mice; Gastrointestinal dysmotility; Constipation; Interstitial cells of Cajal |
| Core Tip |
Baek G, Singh R, Ha SE, Cho H, Padmanabhan S, Vishwanath V, Kim MS, Seon D, You J, Lee MY, Ro S. miR-10a-5p and miR-10b-5p restore colonic motility in aged mice. World J Gastroenterol 2025; In press Core Tip: Gastrointestinal (GI) dysmotility is strongly associated with aging, driven by functional changes in the gut. We previously identified miR-10b-5p as a key regulator of GI motility disorders. However, the specific roles of miR-10a-5p and miR-10b-5p in age-related GI dysmotility remain unexplored. This study presents compelling evidence supporting the miR-10a-5p and miR-10b-5p as critical regulators of interstitial cells of Cajal growth and function, playing essential roles in maintaining GI motility in aged mice and humans. Restoration of these miRNAs through miR-10a-5p and miR-10b-5p mimics in aged mice effectively alleviated GI dysmotility, particularly constipation, offering a promising therapeutic strategy for age-related GI motility disorders. |
| Citation |
Baek G, Singh R, Ha SE, Cho H, Padmanabhan S, Vishwanath V, Kim MS, Seon D, You J, Lee MY, Ro S. miR-10a-5p and miR-10b-5p restore colonic motility in aged mice. World J Gastroenterol 2025; In press |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
