Publication Name	World Journal of Gastroenterology
Manuscript ID	104523
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Mixed lineage kinase domain-like protein in liver diseases: Cell-type-specific functions and dual roles
Manuscript Source	Invited Manuscript
All Author List	Ming-Xing Liang, Ying Zhou, Su-Qun Li, Wan-Sheng Xiang, Zong-Qin Pan, Ying-Hua Chen and Yi-Huai He
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Planning Projects of Guizhou Province No. QKHJC-ZK[2022]YB642 Health Research Project of Guizhou Province No. gzwkj2024-324 Health Research Project of Guizhou Province No. gzwkj2024-103 WBE Liver Fibrosis Foundation No. CFHPC2025028 Beijing Liver and Gallbladder Mutual Aid Public Welfare Foundation Artificial Liver Special Fund No. iGandanF-1082024-Rgg018 Student Innovation and Entrepreneurship Training Program of Zunyi Medical University No. S2024106612360
Corresponding Author	Yi-Huai He, MD, Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Huichuan District, Zunyi 563000, Guizhou Province, China. 993565989@qq.com
Key Words	Cell-type-specific functions; Dual roles; Liver diseases; Mixed lineage kinase domain-like protein; Necroptosis
Core Tip	Mixed lineage kinase domain-like protein (MLKL) functions to mediate necroptosis, inhibit autophagy, and regulate inflammatory responses. The MLKL exhibits different functions in various types of liver cells, leading to diverse manifestations of different liver diseases. This complexity not only brings challenges in understanding the roles of MLKL in liver diseases, but also presents an obstacle in developing therapeutic strategies for targeting MLKL. Here, we briefly review the functions of MLKL and analyze its specific roles in different types of liver cells, aiming to provide clear strategies for precisely targeting MLKL in the treatment of liver diseases.
Citation	Liang MX, Zhou Y, Li SQ, Xiang WS, Pan ZQ, Chen YH, He YH. Mixed lineage kinase domain-like protein in liver diseases: Cell-type-specific functions and dual roles. World J Gastroenterol 2025; In press

Received	2024-12-24 06:38
Peer-Review Started	2024-12-24 06:39
To Make the First Decision
Return for Revision	2025-02-13 23:31
Revised	2025-02-25 09:32
Second Decision	2025-03-13 02:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-13 03:18
Articles in Press	2025-03-13 03:18
Publication Fee Transferred
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ISSN	1007-9327 (print) and 2219-2840 (online)
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