Publication Name	World Journal of Gastroenterology
Manuscript ID	104525
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Triglyceride-glucose index in predicting gastric cancer prognosis: A need for caution
Manuscript Source	Invited Manuscript
All Author List	Yi-Fan Zhao, Jia-Hui Lv, De-Fang Chen, Zhi-Hui Wang, Yun Teng, Michael Ntim, Min Xia, Shao Li and Bin Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Sciences Foundation of China 82301700 and 82471464 Liaoning Province Natural Science Foundation Project 2023-MS-266 and 2024-MS-157 Youth Talent Cultivation Fund Key Project of Dalian Medical University Scientific Research Projects from Wuhan Municipal Health Commission WX23Z26 Research Project Plan of the Qingpu Branch of Zhongshan Hospital QYT2023-02
Corresponding Author	Bin Wang, Liaoning Provincial Key Laboratory of Cerebral Diseases, College of Basic Medical Sciences, National-Local Joint Engineering Research Center for Drug Research, Dalian Medical University, No. 9 West Section, Lvshun South Road, Dalian 116000, Liaoning Province, China. wb101900@126.com
Key Words	Triglyceride-glucose index; Gastric cancer; Prognostic biomarker; Glycolipid metabolism; Overall survival; Progression-free survival
Core Tip	The triglyceride-glucose index, a straightforward marker of insulin resistance, demonstrates potential as a prognostic tool for gastric cancer, correlating with diminished overall survival and progression-free survival. However, its limited cancer specificity, inconsistent cutoff values, and ambiguous mechanistic role in tumor progression necessitate cautious interpretation. Future research should aim to integrate the triglyceride-glucose index with other cancer-specific biomarkers to enhance prognosis prediction and tailor treatment strategies. Prospective, multicenter studies are crucial for validating its clinical utility.
Citation	<p>Zhao YF, Lv JH, Chen DF, Wang ZH, Teng Y, Ntim M, Xia M, Li S, Wang B. Triglyceride-glucose index in predicting gastric cancer prognosis: A need for caution. <i>World J Gastroenterol</i> 2025; 31(18): 104525</p>

Received	2024-12-24 06:23
Peer-Review Started	2024-12-24 06:23
To Make the First Decision
Return for Revision	2025-02-18 02:29
Revised	2025-03-02 16:15
Second Decision	2025-03-27 02:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-27 06:02
Articles in Press	2025-03-27 06:02
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-03-28 07:36
Typeset the Manuscript	2025-05-07 00:52

ISSN	1007-9327 (print) and 2219-2840 (online)
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