Publication Name	World Journal of Gastroenterology
Manuscript ID	104528
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Rethinking carnitine palmitoyltransferase-II and liver stem cells in metabolic dysfunction-associated fatty liver disease-related hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Hong Cai, Chun-Hui Yang and Peng Gao
Funding Agency and Grant Number
Corresponding Author	Peng Gao, PhD, Professor, Department of Clinical Laboratory, The Second Hospital of Dalian Medical University, No. 467 Zhongshan Road, Dalian 116023, Liaoning Province, China. gaop@dmu.edu.cn
Key Words	Metabolic dysfunction-associated fatty liver disease; Carnitine palmitoyltransferase-II; Hepatocellular carcinoma; Liver cancer stem cells; Mitochondrial dysfunction; Metabolic dysfunction
Core Tip	This article reviews a recent study by Wang et al investigating how carnitine palmitoyltransferase-II inactivity drives malignant progression in metabolic dysfunction-associated fatty liver disease through aberrant lipid metabolism, T-cell dysfunction, and liver cancer stem cells activation. Their work revealed that mitochondrial damage and reduced carnitine palmitoyltransferase-II activity under lipid-rich conditions may be early indicators of liver cancer risk, influencing immune cell profiles and the stem cell-like properties of hepatocytes. Understanding these processes could pave the way for novel preventative and therapeutic interventions targeting the metabolic and immunological underpinnings of metabolic dysfunction-associated fatty liver disease-related hepatocarcinogenesis.
Citation	Cai H, Yang CH, Gao P. Rethinking carnitine palmitoyltransferase-II and liver stem cells in metabolic dysfunction-associated fatty liver disease-related hepatocellular carcinoma. World J Gastroenterol 2025; In press

Received	2024-12-28 10:25
Peer-Review Started	2024-12-28 10:25
To Make the First Decision
Return for Revision	2025-02-20 02:41
Revised	2025-02-27 01:56
Second Decision	2025-03-13 02:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-13 03:09
Articles in Press	2025-03-13 03:09
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-03-18 00:17
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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