Publication Name	World Journal of Hepatology
Manuscript ID	104622
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Combining nutraceuticals and a mediterranean diet for managing metabolic dysfunction associated with steatotic liver disease
Manuscript Source	Invited Manuscript
All Author List	Fei-Yong Cheng, Cong Chen, Feng-Yong Wang and Bo-Huan Zhao
Funding Agency and Grant Number
Corresponding Author	Bo-Huan Zhao, Chief Physician, Postdoctoral Fellow, Senior Researcher, Department of General Surgery, Zhuji Traditional Chinese Medicine Hospital, No. 521 Donger Road, Huandong Street, Zhuji 311899, Zhejiang Province, China. 448322750@qq.com
Key Words	Alpha-lipoic acid; Dietary interventions; Metabolic dysfunction-associated steatotic liver disease; Silybum marianum; Synergistic effects; Vitamin E
Core Tip	This study demonstrated the therapeutic potential of combining α-lipoic acid and Silybum marianum supplementation with a Mediterranean diet for the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD). While the intervention reduced visceral adiposity and improved hepatic steatosis markers, key metabolic parameters, including transaminase levels and lipid profiles, remained unchanged. Future investigations should prioritize (1) Mechanistic studies on antioxidant and anti-inflammatory pathways; (2) Exploration of synergistic combinations with complementary nutraceuticals; and (3) Extended follow-up periods to evaluate long-term efficacy and safety. Importantly, patient stratification accounting for disease severity and comorbidity profiles will be essential for developing personalized treatment strategies in MASLD management.
Citation	<p>Cheng FY, Chen C, Wang FY, Zhao BH. Combining nutraceuticals and a mediterranean diet for managing metabolic dysfunction associated with steatotic liver disease. <i>World J Hepatol</i> 2025; 17(4): 104622</p>

Received	2024-12-26 06:28
Peer-Review Started	2024-12-30 01:28
To Make the First Decision
Return for Revision	2025-02-26 08:56
Revised	2025-02-26 15:01
Second Decision	2025-03-06 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-06 10:26
Articles in Press	2025-03-06 10:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-04-01 01:30

ISSN	1948-5182 (online)
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