Publication Name	World Journal of Gastroenterology
Manuscript ID	104758
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Epstein-Barr virus infection is an independent risk factor for surgery in patients with moderate-to-severe ulcerative colitis
Manuscript Source	Unsolicited Manuscript
All Author List	Hui Zhang, Xi Gu, Wei He, Shu-Liang Zhao and Zhi-Jun Cao
Funding Agency and Grant Number	Funding Agency Grant Number General Hospital Integrated Guidance Project of Shanghai Municipal Health Commission and Municipal Administration of Traditional Chinese Medicine (Phase I) ZXXT-202210 "Science and Technology Innovation Action Plan" Medical Innovation Research Project of Shanghai Municipal Science and Technology Commission 22Y11907900
Corresponding Author	Zhi-Jun Cao, Chief, MD, PhD, Professor, Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 145 Middle Shandong Road, Shanghai 200001, China. caozj_renji@163.com
Key Words	Epstein-Barr virus; Cytomegalovirus; Ulcerative colitis; Colectomy; Predictive model
Core Tip	This retrospective single-center observational study investigated the effect of Epstein-Barr virus (EBV) infection of the intestinal mucosa on surgical risk in patients with moderate-to-severe ulcerative colitis (UC). Surgical treatment remains necessary for patients refractory to medical therapy or with severe complications in patients with moderate-to-severe UC. Our study determined that EBV infection of the intestinal mucosa is a significant independent risk factor for colectomy in patients with moderate-to-severe UC. In addition, we developed a new nomogram model including EBV infection to help predict colectomy risk in patients with moderate-to-severe UC.
Citation	Zhang H, Gu X, He W, Zhao SL, Cao ZJ. Epstein-Barr virus infection is an independent risk factor for surgery in patients with moderate-to-severe ulcerative colitis. World J Gastroenterol 2025; In press

Received	2024-12-31 10:02
Peer-Review Started	2024-12-31 10:02
To Make the First Decision
Return for Revision	2025-03-05 01:18
Revised	2025-03-18 18:01
Second Decision	2025-04-14 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-14 05:54
Articles in Press	2025-04-14 05:54
Publication Fee Transferred	2025-03-24 14:15
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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