Publication Name	World Journal of Diabetes
Manuscript ID	104787
Country	United Kingdom

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Monogenic diabetes: An evidence-based clinical approach
Manuscript Source	Invited Manuscript
All Author List	Saptarshi Bhattacharya, Cornelius J Fernandez, Abul Bashar Mohammad Kamrul-Hasan and Joseph M Pappachan
Funding Agency and Grant Number
Corresponding Author	Joseph M Pappachan, MD, Professor, Senior Researcher, Faculty of Science,, Manchester Metropolitan University, All Saints Building, Oxford Road, Manchester M15 6BH, Greater Manchester, United Kingdom. drpappachan@yahoo.co.in
Key Words	Monogenic diabetes; Maturity-onset diabetes of the young; Neonatal diabetes; Mitochondrial diabetes; Insulin resistance syndrome; Monogenic autoimmune diabetes; Next-generation sequencing
Core Tip	Monogenic diabetes is an uncommon form of diabetes caused by single gene mutations. Depending on the type of underlying gene mutation, the disease can present at any age with diverse clinical presentations. The diagnostic workup includes genetic testing and may involve tests like C-peptide assay and autoantibody screening to exclude other forms of diabetes. Next-generation sequencing technologies such as targeted gene panels focusing on known monogenic diabetes genes, and whole-exome sequencing that analyze the protein-coding regions of the genome are replacing older methods like sanger sequencing. Pitfalls in workup can include misdiagnosis as type 1 or type 2 diabetes, leading to inappropriate treatment and potential complications. This evidence-based review updates the current clinical approach to monogenic diabetes.
Citation	Bhattacharya S, Fernandez CJ, Kamrul-Hasan ABM, Pappachan JM. Monogenic diabetes: An evidence-based clinical approach. World J Diabetes 2025; In press

Received	2025-01-02 12:53
Peer-Review Started	2025-01-03 09:02
To Make the First Decision
Return for Revision	2025-02-13 02:06
Revised	2025-02-20 11:39
Second Decision	2025-03-11 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-11 08:55
Articles in Press	2025-03-11 08:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-03-26 02:11

ISSN	1948-9358 (online)
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