Publication Name	World Journal of Radiology
Manuscript ID	104808
Country	China

Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Retrospective Study
Article Title	Computed tomography-guided percutaneous biopsy for assessing tumor heterogeneity in neuroendocrine tumor metastases to the liver
Manuscript Source	Unsolicited Manuscript
All Author List	Lei-Lei Ying, Ke-Ning Li, Wen-Tao Li, Xin-Hong He and Chao Chen
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82072034
Corresponding Author	Chao Chen, PhD, Department of Interventional Radiology, Fudan University Shanghai Cancer Center, No. 270 Dongan Road, Xuhui District, Shanghai 200032, China. chaochen_cc@fudan.edu.cn
Key Words	Tumor heterogeneity; Survival; Liver metastases; Gastroenteropancreatic neuroendocrine tumors; Image-guided core needle biopsy
Core Tip	This study demonstrates that percutaneous computed tomography-guided core needle biopsy effectively identifies clinically significant grading heterogeneity in liver metastases from gastroenteropancreatic neuroendocrine tumors. Notably, 40.2% of patients exhibited grade discrepancies between primary and metastatic sites, with upgraded tumors (e.g., G2 to G3) correlating with markedly reduced overall survival. These findings emphasize percutaneous computed tomography-guided core needle biopsy’s pivotal role in optimizing risk stratification, informing personalized therapeutic decisions (e.g., intensified surveillance or targeted therapies), and improving prognostic accuracy for gastroenteropancreatic neuroendocrine tumor patients, while confirming its safety and diagnostic reliability in clinical practice.
Citation	Ying LL, Li KN, Li WT, He XH, Chen C. Computed tomography-guided percutaneous biopsy for assessing tumor heterogeneity in neuroendocrine tumor metastases to the liver. World J Radiol 2025; In press

Received	2025-01-03 15:56
Peer-Review Started	2025-01-03 15:56
To Make the First Decision
Return for Revision	2025-03-28 00:47
Revised	2025-04-09 11:37
Second Decision	2025-05-08 02:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-08 08:53
Articles in Press	2025-05-08 08:53
Publication Fee Transferred	2025-04-14 02:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8470 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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