Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	104860
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	Associations between blood metabolite levels and gastrointestinal cancer risk: A preliminary untargeted metabolomics study
Manuscript Source	Unsolicited Manuscript
All Author List	Tian-Hao Guo, Wen-Jian Zhu, Yi-Fan Hui, Shuo-Qi Zhao, Ting-Ting Zhou, Xue-Meng Wang, Qin-Chang Zhang, Wei Wang, Liu Li, Wei-Xing Shen, Xiao-Yu Wu and Hai-Bo Cheng
Funding Agency and Grant Number	Funding Agency Grant Number National Key R and D Program of China 2022YFC3500200, 2022YFC3500202 and 2022YFC3500204 Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine ZYYCXTD-C-202208 NATCM’s Project of High-Level Construction of Key TCM Disciplines [2023]85 Qing Lan Project of Jiangsu Higher Education Institutions [2023]27 Jiangsu Postgraduate Practice Innovation Plan SJCX22_0706 General Project of Universities’ Philosophy and Social Science in Jiangsu Province 2024SJYB0564 Jiangsu Provincial Leading Talents Program in Traditional Chinese Medicine SLJ0314
Corresponding Author	Hai-Bo Cheng, Chief Physician, PhD, Professor, The First Clinical Medical College, Nanjing University of Chinese Medicine, No. 138 Xianlin Road, Nanjing 210023, Jiangsu Province, China. 2068324936@qq.com
Key Words	Gastrointestinal cancer; Gastric cancer; Colorectal cancer; Traditional Chinese medicine syndrome; Biological basis; Untargeted metabolomics
Core Tip	This study identified differentially expressed metabolites in colorectal cancer and gastric cancer, unraveling the metabolomic characteristics of spleen deficiency and blood stasis toxin (PXYD) syndrome in gastrointestinal cancers. It preliminarily identified 352 common metabolites and 10 metabolic pathways in gastrointestinal cancers, providing a theoretical basis for the "same treatment for different diseases" approach in PXYD syndrome of gastrointestinal cancers.
Citation	Guo TH, Zhu WJ, Hui YF, Zhao SQ, Zhou TT, Wang XM, Zhang QC, Wang W, Li L, Shen WX, Wu XY, Cheng HB. Associations between blood metabolite levels and gastrointestinal cancer risk: A preliminary untargeted metabolomics study. World J Gastrointest Oncol 2025; In press

Received	2025-01-06 04:56
Peer-Review Started	2025-01-06 04:56
To Make the First Decision
Return for Revision	2025-04-07 11:46
Revised	2025-04-24 16:36
Second Decision	2025-06-06 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-06 07:32
Articles in Press	2025-06-06 07:32
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ISSN	1948-5204 (online)
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