Publication Name	World Journal of Gastroenterology
Manuscript ID	105004
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Efficacy of recombinant human thrombopoietin in patients with acute-on-chronic liver failure and thrombocytopenia: A prospective, open-label study
Manuscript Source	Unsolicited Manuscript
All Author List	Gang Liu, Fei Tang, Tao Wang, Jun-Qing Yan, Feng-Hui Li, Fu-Shuang Ha, Xu Zhang, Li Jing and Jing Liang
Funding Agency and Grant Number	Funding Agency Grant Number Tianjin Key Medical Discipline (Specialty) Construction Project TJYXZDXK-034A
Corresponding Author	Jing Liang, Chief Physician, MD, Department of Gastroenterology and Hepatology, The Third Central Hospital of Tianjin, No. 83 Jintang Road, Tianjin 300170, China. haolele77@sina.com
Key Words	Recombinant human thrombopoietin; Acute-on-chronic liver failure; Thrombocytopenia; Hepatocyte growth factor; Prognosis
Core Tip	Patients with acute-on-chronic liver failure (ACLF) have a high mortality rate and poor prognosis. They often experience concurrent thrombocytopenia and bleeding events. This study aimed to evaluate the efficacy and safety of recombinant human thrombopoietin (rhTPO) in ACLF patients with concomitant severe thrombocytopenia. We assigned 70 ACLF patients with severe thrombocytopenia into the rhTPO group and the control group, with 35 patients in each group. Patients in the rhTPO group received subcutaneous injections of rhTPO for 7 consecutive days, while those in the control group did not receive rhTPO treatment. The platelet count in the rhTPO group increased significantly from the baseline. The model for end-stage liver disease score, albumin level, and international normalized ratio in patients of the rhTPO group improved significantly from the baseline on day 14 after rhTPO injection. In summary, rhTPO can significantly increase the platelet count in ACLF patients with thrombocytopenia, help improve liver function, and reduce the occurrence of bleeding events. It also has a good safety profile.
Citation	<p>Liu G, Tang F, Wang T, Yan JQ, Li FH, Ha FS, Zhang X, Jing L, Liang J. Efficacy of recombinant human thrombopoietin in patients with acute-on-chronic liver failure and thrombocytopenia: A prospective, open-label study. <i>World J Gastroenterol</i> 2025; 31(14): 105004</p>

Received	2025-01-08 08:35
Peer-Review Started	2025-01-08 08:35
To Make the First Decision
Return for Revision	2025-02-12 10:32
Revised	2025-02-24 06:27
Second Decision	2025-03-24 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-24 07:09
Articles in Press	2025-03-24 07:09
Publication Fee Transferred	2025-03-02 09:22
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-04-01 01:25

ISSN	1007-9327 (print) and 2219-2840 (online)
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