Publication Name	World Journal of Clinical Oncology
Manuscript ID	105117
Country	India

Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Oncogenic B-Raf proto-oncogene, serine/threonine kinase-mediated hedgehog signalling in the pathogenesis and targeted therapy of melanoma
Manuscript Source	Invited Manuscript
All Author List	Rafiq A Rather
Funding Agency and Grant Number	Funding Agency Grant Number Science and Engineering Research Board No. PDF/2016/002730
Corresponding Author	Rafiq A Rather, Assistant Professor, PhD, Department of Clinical Biochemistry, Govt. Degree College Shopian, Gagren, Shopian 192303, Jammu and Kashmir, India. rafiqahmad11@gmail.com
Key Words	Melanoma; Hedgehog signaling; Acetylation; Mutations; Stem cells; Glioma-associated oncogene homolog; Targeted therapy
Core Tip	Oncogenic B-Raf proto-oncogene, serine/threonine kinase activates the hedgehog signaling pathway, triggering glioma-associated oncogene homolog (GLI) 1/2 transcription factors that promote melanoma cell invasion and sustain cancer stem cell self-renewal, contributing to the malignancy’s therapeutic resistance. Histone deacetylases 1/2 (HDAC1/2) suppress the acetylation of GLI1/2, facilitating their activation. Inhibiting HDAC1/2 may stabilize GLI proteins in their inactive, acetylated form, offering a novel approach to inhibit melanoma progression. Hedgehog signaling induces HDAC1/2 expression, creating a feedback loop that amplifies GLI-mediated transcription, promoting cancer stem cell renewal. Disrupting this loop could unveil new therapeutic avenues for overcoming melanoma’s resistance to treatment.
Citation	Rather RA. Oncogenic B-Raf proto-oncogene, serine/threonine kinase-mediated hedgehog signalling in the pathogenesis and targeted therapy of melanoma. World J Clin Oncol 2025; In press

Received	2025-01-13 09:45
Peer-Review Started	2025-01-13 09:45
To Make the First Decision
Return for Revision	2025-05-12 10:00
Revised	2025-05-26 13:54
Second Decision	2025-09-03 02:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-03 10:04
Articles in Press	2025-09-03 10:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com