Publication Name	World Journal of Stem Cells
Manuscript ID	105266
Country	China

Category	Transplantation
Manuscript Type	Basic Study
Article Title	Human umbilical cord mesenchymal stem cells ameliorate liver metabolism in diabetic rats with metabolic-associated fatty liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Ke-Bing Zhou, Li Nie, Mei-Li Wang, Dong-Hua Xiao, Hai-Yan Zhang, Xia Yang, Duan-Fang Liao and Xue-Feng Yang
Funding Agency and Grant Number	Funding Agency Grant Number National Key Specialty Major Scientific Research Project of the Hunan Provincial Health Commission Z2023158
Corresponding Author	Xue-Feng Yang, PhD, Professor, Department of Gastroenterology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, No. 336 Dongfeng South Road, Zhuhui District, Hengyang 421002, Hunan Province, China. yxf9988@126.com
Key Words	Human umbilical cord mesenchymal stem cells; Diabetes mellitus; Metabolic-associated fatty liver disease; Blood glucose; Triglyceride; Liver function; Liver metabolism
Core Tip	Current treatment methods for diabetes mellitus (DM) with metabolic-associated fatty liver disease (MAFLD) remain limited, and there is an urgent need to identify novel and effective therapeutic strategies. In this study, a rat model of DM with MAFLD was established using streptozotocin, and human umbilical cord mesenchymal stem cell were administered via tail vein injection as an intervention. Our findings showed that human umbilical cord mesenchymal stem cell alleviate liver metabolic disturbances in diabetic rats with MAFLD, consequently mitigating the pathological state of DM and slowing the progression of MAFLD.
Citation	Zhou KB, Nie L, Wang ML, Xiao DH, Zhang HY, Yang X, Liao DF, Yang XF. Human umbilical cord mesenchymal stem cells ameliorate liver metabolism in diabetic rats with metabolic-associated fatty liver disease. World J Stem Cells 2025; In press

Received	2025-02-12 06:57
Peer-Review Started	2025-02-18 00:44
To Make the First Decision
Return for Revision	2025-03-05 09:17
Revised	2025-03-17 09:51
Second Decision	2025-04-28 01:20
Accepted by Journal Editor-in-Chief	2025-05-02 06:46
Accepted by Executive Editor-in-Chief	2025-05-09 07:15
Articles in Press	2025-05-09 07:15
Publication Fee Transferred	2025-03-21 04:53
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ISSN	1948-0210 (online)
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