Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	105321
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	LncRNA SNHG5 modulates cell proliferation and migration through the miR-92a-3p/BTG2 axis in gastric cancer by the PI3K/AKT pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Qi-Qi Mao, Mei-Lin Zhang, Liang Zhong, Xu-Dong Xu, Xin-Hai Wang, Du-Yi Pan, Fu-Sheng Zhou, Jia-Xin Huang, Xian-Guang Zhao, Jia-Jie Chen, Xiao-Yun Jiang, Xu Sun and Wei-Qun Ding
Funding Agency and Grant Number
Corresponding Author	Liang Zhong, Chief Physician, Department of Gastroenterology, Huashan Hospital, Fudan University, No. 12 Urumqi Middle Road, Shanghai 201907, China. ifb422@yeah.net
Key Words	PI3K/AKT signaling pathway; B-cell translocation gene 2; Gastric cancer; Long non-coding RNAs small nucleolar RNA host gene 5; Non-coded RNA; Cell proliferation
Core Tip	This study emphasizes the role of lncRNA SNHG5 as a tumor-suppression factor in gastric cancer (GC). SNHG5 acts as a competing endogenous RNA by reducing levels of miR-92a-3p, leading to increased levels of BTG2, a tumor suppressor gene. This ultimately leads to the inhibition of GC cell proliferation and migration by inhibiting the PI3K/AKT signaling pathway. This is the first time that an SNHG5/miR-92a-3p/BTG2 axis has been discovered to contribute to the progression of GC. This molecular understanding aids in providing an attractive target for therapy and will contribute to a framework of RNA-based approaches to diagnosing and treating GC.
Citation	Mao QQ, Zhang ML, Zhong L, Xu XD, Wang XH, Pan DY, Zhou FS, Huang JX, Zhao XG, Chen JJ, Jiang XY, Sun X, Ding WQ. LncRNA SNHG5 modulates cell proliferation and migration through the miR-92a-3p/BTG2 axis in gastric cancer by the PI3K/AKT pathway. World J Gastrointest Oncol 2025; In press

Received	2025-01-21 08:53
Peer-Review Started	2025-01-21 08:53
To Make the First Decision
Return for Revision	2025-03-19 03:20
Revised	2025-03-25 14:37
Second Decision	2025-06-16 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-16 09:29
Articles in Press	2025-06-16 09:29
Publication Fee Transferred	2025-04-01 09:56
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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