Publication Name	World Journal of Gastroenterology
Manuscript ID	105346
Country	Russia

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Metabolic dysfunction-associated steatotic liver disease: A story of muscle and mass
Manuscript Source	Invited Manuscript
All Author List	Vasily Isakov
Funding Agency and Grant Number	Funding Agency Grant Number Russian Science Foundation No. 19-76-30014
Corresponding Author	Vasily Isakov, MD, PhD, Professor, Department of Gastroenterology and Hepatology, Federal Research Center of Nutrition, Biotechnology and Food Safety, 21 Kashirskoye Shosse, Moscow 115446, Russia. vasily.isakov@gmail.com
Key Words	Metabolic dysfunction-associated steatotic liver disease; Skeletal muscle alterations; Sarcopenia; Skeletal muscle mass index; Myosteatosis; Dietary patterns; High-protein diet; Physical activity; Glucagon-like peptide-1 receptor agonists
Core Tip	Skeletal muscle alterations, such as sarcopenia, myosteatosis, and altered muscle metabolism, are highly prevalent in metabolic dysfunction-associated steatotic liver disease (MASLD) and are increasingly recognized as both contributors and consequences of MASLD, affecting disease progression and outcomes. Common treatment approaches for both conditions include nutritional interventions and physical activity/exercise aimed at increasing insulin sensitivity and reducing fat mass but maintaining muscle mass and function. Pharmacological agents that target the muscle and liver (such as glucagon-like peptide-1 receptor agonists) show promise, but have not yet been approved for the treatment of MASLD.
Citation	Isakov V. Metabolic dysfunction-associated steatotic liver disease: A story of muscle and mass. World J Gastroenterol 2025; In press

Received	2025-01-20 07:25
Peer-Review Started	2025-01-20 07:25
To Make the First Decision
Return for Revision	2025-04-09 06:40
Revised	2025-04-13 12:59
Second Decision	2025-05-09 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-09 06:47
Articles in Press	2025-05-09 06:47
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ISSN	1007-9327 (print) and 2219-2840 (online)
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