| Category |
Oncology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Exploring the gut microbiome’s influence on cancer-associated anemia: Mechanisms, clinical challenges, and innovative therapies
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Ayrton Bangolo, Behzad Amoozgar, Maryam Habibi, Elizabeth Simms, Vignesh K Nagesh, Shruti Wadhwani, Nikita Wadhwani, Auda Auda, Daniel Elias, Charlene Mansour, Robert Abbott, Nisrene Jebara, Lili Zhang, Sarvarinder Gill, Kareem Ahmed, Andrew Ip, Andre Goy and Christina Cho |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Ayrton Bangolo, Department of Hematology and Oncology, John Theurer Cancer Center, 92 2nd Street, Hackensack, NJ 07601, United States. ayrton.bangolo@hmhn.org |
| Key Words |
Microbiome-targeted therapies; Systemic inflammation; Iron metabolism; Dysbiosis; Cancer-associated anemia; Gut microbiome |
| Core Tip |
The gut microbiome is increasingly recognized as a pivotal factor in cancer-associated anemia, influencing its pathophysiology, clinical manifestations, and potential therapeutic strategies. Dysbiosis, or microbial imbalance, is common in cancer patients and exacerbates anemia through mechanisms such as impaired iron absorption, heightened systemic inflammation, and suppression of erythropoiesis. Emerging evidence highlights how gut microbiota modulates iron metabolism, inflammatory cytokine production, and immune responses, linking microbial health directly to anemia severity. Promising interventions, including probiotics, prebiotics, fecal microbiota transplantation, and dietary modifications, aim to restore microbial balance, optimize iron bioavailability, and reduce inflammation. As research advances, microbiome-targeted therapies could transform anemia management, integrating seamlessly with existing treatments and offering personalized solutions for oncology patients. Further studies are needed to refine these approaches and establish microbiome-based biomarkers for anemia prediction and therapeutic monitoring. |
| Citation |
Bangolo A, Amoozgar B, Habibi M, Simms E, Nagesh VK, Wadhwani S, Wadhwani N, Auda A, Elias D, Mansour C, Abbott R, Jebara N, Zhang L, Gill S, Ahmed K, Ip A, Goy A, Cho C. Exploring the gut microbiome’s influence on cancer-associated anemia: Mechanisms, clinical challenges, and innovative therapies. World J Gastrointest Pharmacol Ther 2025; In press |
| ISSN |
2150-5349 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
