Publication Name	World Journal of Methodology
Manuscript ID	105478
Country	United Kingdom

Category	Endocrinology & Metabolism
Manuscript Type	Systematic Reviews
Article Title	Safety and efficacy of glucagon-like peptide-1 receptor agonists in type 2 diabetes mellitus during Ramadan: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Abul Bashar Mohammad Kamrul-Hasan, Joseph M Pappachan, Hamid K Ashraf, Lakshmi Nagendra, Deep Dutta, Mohammad Shafi Kuchay and Shehla Shaikh
Funding Agency and Grant Number
Corresponding Author	Joseph M Pappachan, FRCP, MD, Professor, Senior Researcher, Faculty of Science, Manchester Metropolitan University, All Saints Building, Manchester M156BH, Greater Manchester, United Kingdom. drpappachan@yahoo.co.in
Key Words	Type 2 diabetes mellitus; Glucagon-like peptide-1 receptor agonist; Ramadan; Religious fasting; Safety; Meta-analysis
Core Tip	No systematic review and meta-analysis (MA) have previously assessed the safety and efficacy of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in individuals with type 2 diabetes mellitus who fast during Ramadan. This MA of 4 studies with 754 participants from 11 countries identified that GLP-1RAs are safe with only exaggerated gastrointestinal side effects, mainly nausea and vomiting. GLP-1RA also appears to be effective in improving glycated hemoglobin and helping weight loss compared to other glucose-lowering medications. However, other cardiometabolic benefits like blood pressure and lipid profile improvement were not evident. Larger multinational, randomized trials with wider global participation are necessary for making firmer clinical practice recommendations for using GLP-1RAs during Ramadan fasting.
Citation	Kamrul-Hasan ABM, Pappachan JM, Ashraf HK, Nagendra L, Dutta D, Kuchay MS, Shaikh S. Safety and efficacy of glucagon-like peptide-1 receptor agonists in type 2 diabetes mellitus during Ramadan: A systematic review. World J Methodol 2025; In press

Received	2025-01-24 09:08
Peer-Review Started	2025-01-24 09:08
To Make the First Decision
Return for Revision	2025-04-15 02:55
Revised	2025-04-17 21:15
Second Decision	2025-06-03 02:55
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-03 08:50
Articles in Press	2025-06-03 08:50
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ISSN	2222-0682 (online)
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