Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	105570
Country	China

Category	Pharmacology & Pharmacy
Manuscript Type	Basic Study
Article Title	Oxocrebanine inhibits the proliferation of hepatoma Hep3b2.1-7 cells by promoting apoptosis and autophagy
Manuscript Source	Unsolicited Manuscript
All Author List	Zheng-Wen Wang, Cai-Yan Pan, Cang-Long Wei, Hui Liao, Xiao-Po Zhang, Cai-Yun Zhang and Lei Yu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82060778 the Hainan Provincial Natural Science Foundation of China 820RC776 the Hainan Province Health Science and Technology Innovation Joint Project WSJK2024MS162 the Heilongjiang Province Scientific Research Project of Traditional Chinese Medicine ZHY2024-098
Corresponding Author	Cai-Yun Zhang, Senior Researcher, Hainan Pharmaceutical Research and Development Science and Technology Park, Hainan Pharmaceutical Research and Development Science and Technology Park, Intersection of mei'an 3rd Street and anling 3rd road, Xiu Ying District, Haikou, 570312, China, Haikou 570312, Hainan Province, China. zhangcaiyunhaikou@163.com
Key Words	Stephania hainannensis H.S. Lo et Y. Tsoong; Oxocrebanine; Hepatoma cancer Hep3B2.1-7 cells; Apoptosis; Autophagy
Core Tip	The present study revealed that oxocrebanine can inhibit the proliferation of hepatoma cells by promoting apoptosis and inducing autophagy both in vitro and in vivo. Oxocrebanine can induce apoptosis in Hep3b2.1-7 cells upregulating c-caspase-3, Bax, and Bak protein expression levels and downregulating PARP1, Bcl-2, and Mcl-1 protein expression levels. The inhibition of Hep3b2.1-7 cells proliferation by oxocrebanine may be related to the induction of protective autophagy. The results of the TUNEL assay and immunohistochemistry also revealed that oxocrebanine induced apoptosis in vivo and increased the expression level of LC3, an autophagy marker.
Citation	Wang ZW, Pan CY, Wei CL, Liao H, Zhang XP, Zhang CY, Yu L. Oxocrebanine inhibits the proliferation of hepatoma Hep3b2.1-7 cells by promoting apoptosis and autophagy. World J Gastrointest Oncol 2025; In press

Received	2025-02-18 08:47
Peer-Review Started	2025-02-18 08:47
To Make the First Decision
Return for Revision	2025-03-06 07:09
Revised	2025-03-28 08:40
Second Decision	2025-05-08 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-08 07:40
Articles in Press	2025-05-08 07:40
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-05-12 01:59
Typeset the Manuscript

ISSN	1948-5204 (online)
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