Publication Name	World Journal of Diabetes
Manuscript ID	105592
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Prospective Study
Article Title	Identification and validation of serum amino acids as diagnostic biomarkers for diabetic peripheral neuropathy
Manuscript Source	Unsolicited Manuscript
All Author List	Wei-Sheng Xu, Huan Xing, Qing-Qing Wang, Hui Qi, Jian-Tao He, Tong Jin, Yan-Peng Kan, Shi-Yu Sun, Ji-Ying Wang and Fu-Qing Lin
Funding Agency and Grant Number	Funding Agency Grant Number the Youth Fund for Specialized Clinical Research of the Health Commission 20214Y0149
Corresponding Author	Fu-Qing Lin, Chief Physician, Department of Pain Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301 Yanchang Middle Road, Jingan District, Shanghai 200072, China. fuqinglin@tongji.edu.cn
Key Words	Diabetic peripheral neuropathy; Type 2 diabetes mellitus; Arginine; Tyrosine; Glutamic acid
Core Tip	This study involves the most extensive identification of serum amino acids as biomarkers for the detection of diabetic peripheral neuropathy (DPN), including the use of both training and validation cohorts. This is the first study demonstrating that a signature consisting of 3 serum amino acids (arginine, tyrosine, and glutamic acid) and diabetes duration can successfully distinguish DPN from type 2 diabetes mellitus with acceptable accuracy. Thirteen DPN patients received treatment in our department, and their clinical symptoms were relieved; moreover, their serum arginine and tyrosine levels were significantly increased, which may reflect the reliability of our model. These findings may provide potential therapeutic targets for the diagnosis and treatment of DPN.
Citation	Xu WS, Wang QQ, Xing H, Qi H, He JT, Jin T, Kan YP, Sun SY, Wang JY, Lin FQ. Identification and validation of serum amino acids as diagnostic biomarkers for diabetic peripheral neuropathy. World J Diabetes 2025; In press

Received	2025-01-30 06:55
Peer-Review Started	2025-01-30 06:55
To Make the First Decision
Return for Revision	2025-03-14 11:01
Revised	2025-03-27 17:37
Second Decision	2025-05-07 01:46
Accepted by Journal Editor-in-Chief	2025-05-12 16:06
Accepted by Executive Editor-in-Chief	2025-05-14 07:19
Articles in Press	2025-05-14 07:19
Publication Fee Transferred	2025-03-31 13:57
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ISSN	1948-9358 (online)
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