Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	105712
Country	China

Category	Oncology
Manuscript Type	Minireviews
Article Title	Progress in the treatment of duodenal cancer: A comprehensive review
Manuscript Source	Unsolicited Manuscript
All Author List	Liang-Gong Liao, Zhi-Guo Xiong and Jun-Jie Hu
Funding Agency and Grant Number	Funding Agency Grant Number Research Projects of Biomedical Center of Hubei Cancer Hospital 2022SWZX07 the 2023-2024 Annual Scientific Research Project of Traditional Chinese Medicine from Hubei Provincial Administration of Traditional Chinese Medicine ZY2023Z005 Health Commission of Hubei Province Scientific Research Project WJ2023Z011
Corresponding Author	Jun-Jie Hu, MD, Department of Gastrointestinal Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 116 Zuodaoquan South Road, Wuhan 430079, Hubei Province, China. 791462122@qq.com
Key Words	Duodenal cancer; Surgical resection; Chemotherapy; Targeted therapies; Immunotherapy
Core Tip	Duodenal cancer, a rare gastrointestinal malignancy (< 0.5/100000 incidence), requires multidisciplinary strategies. Endoscopic resection for early-stage tumors improves survival and reduces infection mortality. Advanced cases benefit from surgery and minimally invasive techniques. Chemotherapy and neoadjuvant chemoradiotherapy enhance outcomes. Targeted therapies such as erb-b2 receptor tyrosine kinase 2 (human epidermal growth factor receptor 2)/phosphatidylinositol-3-kinase inhibitors and immunotherapy show transformative potential. Molecular profiling guides precision medicine. International collaboration is critical to optimize biomarker-driven strategies and improve survival. This review integrates innovations in surgery, systemic therapy, and immunotherapy, offering a roadmap for personalized management.
Citation	Liao LG, Xiong ZG, Hu JJ. Progress in the treatment of duodenal cancer: A comprehensive review. World J Gastrointest Oncol 2025; In press

Received	2025-02-05 04:39
Peer-Review Started	2025-02-05 04:39
To Make the First Decision
Return for Revision	2025-03-25 07:10
Revised	2025-04-04 08:55
Second Decision	2025-05-30 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-30 07:25
Articles in Press	2025-05-30 07:25
Publication Fee Transferred	2025-04-11 04:31
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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