Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	105723
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Neutrophil extracellular traps predict sensitivity to neoadjuvant chemotherapy combined with immunotherapy in locally advanced gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Yuan Lv, Wei-Xuan Li, Liang Sun, Lin-Pu Xin, Tao Li, Wen-Tao Zhong, Hong-Yan Zhu, Ran An, Ai-Jun Liu and Lin Chen
Funding Agency and Grant Number
Corresponding Author	Lin Chen, Assistant Professor, Medical School of Chinese PLA, No. 28 FuXinglu, Haidian District, Beijing 100089, China. chenlinbj301@163.com
Key Words	Neutrophil extracellular traps; Locally advanced gastric cancer; Neoadjuvant chemotherapy; Neoadjuvant immunotherapy; Treatment sensitivity
Core Tip	This study identified neutrophil extracellular traps (NETs) as a novel prognostic and predictive biomarker for neoadjuvant chemotherapy combined with immunotherapy (NACI) in locally advanced gastric cancer (LAGC). Low pretreatment NET density correlated with higher pathological complete response and overall response rates, while increased post-treatment NET density was associated with poorer outcomes. These findings suggest that targeting NET formation could enhance NACI efficacy, offering a potential therapeutic strategy for LAGC patients.
Citation	Lv Y, Li WX, Sun L, Xin LP, Li T, Zhong WT, Zhu HY, An R, Liu AJ, Chen L. Neutrophil extracellular traps predict sensitivity to neoadjuvant chemotherapy combined with immunotherapy in locally advanced gastric cancer. World J Gastrointest Oncol 2025; In press

Received	2025-02-05 04:17
Peer-Review Started	2025-02-05 04:18
To Make the First Decision
Return for Revision	2025-03-27 09:43
Revised	2025-05-01 08:23
Second Decision	2025-06-05 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-05 08:03
Articles in Press	2025-06-05 08:03
Publication Fee Transferred	2025-05-08 08:00
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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