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Publication Name World Journal of Gastroenterology
Manuscript ID 105729
Country China
Category Cell Biology
Manuscript Type Basic Study
Article Title Chaperonin-containing tailless complex polypeptide 1 subunit 6A negatively regulates autophagy and protects colorectal cancer cells from cisplatin-induced cytotoxicity
Manuscript Source Unsolicited Manuscript
All Author List Jian-Xing Ma, Xiao-Jun Li, Ya-Long Li, Ming-Chan Liu, Rui-Hang Du, Yi Cheng, Liang-Jie Li, Zhi-Ying Ai, Jian-Tao Jiang and Si-Yuan Yan
Funding Agency and Grant Number
Funding Agency Grant Number
Shandong Provincial Natural Science Foundation ZR2023MH329
Project of Shandong Province Higher Educational Youth Innovation Science and Technology Program 2023KJ263
Natural Science Foundation of Gansu Province, China 22JR5RA953
Corresponding Author Si-Yuan Yan, Associate Professor, PhD, Precision Medicine Laboratory for Chronic Non-communicable Diseases of Shandong Province, Institute of Precision Medicine, Jining Medical University, No. 133 Hehua Road, Jining 272067, Shandong Province, China. yansy@mail.jnmc.edu.cn
Key Words Chaperonin-containing tailless complex polypeptide 1 subunit 6a; Cisplatin; Autophagy; Colorectal cancer; Necroptosis
Core Tip This study delves into the role of chaperonin-containing tailless complex polypeptide 1 subunit 6A (CCT6A), a protein folding chaperone, in CRC therapy. Our findings reveal that CCT6A expression is downregulated by cisplatin (DDP) in CRC cells, enhancing DDP's cytotoxicity. Depletion of CCT6A further potentiates DDP's effects by promoting autophagy, apoptosis, and necroptosis, while its overexpression provides resistance. Using immunoblotting and autophagy assays, we confirmed CCT6A's negative regulatory role in autophagy. Markers of apoptosis and necroptosis were upregulated in CCT6A-depleted cells, indicating increased cell death. Autophagy inhibition exacerbated cell death, compromising viability and proliferation. Thus, CCT6A emerges as a potential therapeutic target in CRC, modulating key cellular processes and enhancing DDP efficacy.
Citation Ma JX, Li XJ, Li YL, Liu MC, Du RH, Cheng Y, Li LJ, Ai ZY, Jiang JT, Yan SY. Chaperonin-containing tailless complex polypeptide 1 subunit 6A negatively regulates autophagy and protects colorectal cancer cells from cisplatin-induced cytotoxicity. World J Gastroenterol 2025; In press
Received
2025-02-05 03:01
Peer-Review Started
2025-02-05 03:01
To Make the First Decision
Return for Revision
2025-03-17 20:03
Revised
2025-03-27 12:11
Second Decision
2025-04-14 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-04-14 06:09
Articles in Press
2025-04-14 06:09
Publication Fee Transferred
2025-03-28 01:02
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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