Publication Name	World Journal of Transplantation
Manuscript ID	105905
Country	France

Category	Transplantation
Manuscript Type	Case Report
Article Title	Toxic agranulocytosis following nitazoxanide treatment for norovirus diarrhea in a kidney transplant recipient: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Dorian Grépilloux, Corentin Guéneau, Jules Weinhard, Rémi Richaud, Eloi Chevallier, Thomas Jouve, Julien Dusserre and Lionel Rostaing
Funding Agency and Grant Number
Corresponding Author	Lionel Rostaing, MD, PhD, Professor, Department of Nephrology, Hemodialysis, Apheresis, and Kidney Transplantation, Grenoble University Hospital, CS10217, Grenoble 38043, France. lrostaing@chu-grenoble.fr
Key Words	Agranulocytosis; Neutropenia; Nitazoxanide; Norovirus; Iatrogeny; Case report
Core Tip	Nitazoxanide is a thiazolide compound. The Food and Drug Administration has approved it for the treatment of Giardia intestinalis and Cryptosporidium parvum infections in immunocompromised patients aged 12 years or older. In immunocompromised patients, nitazoxanide use for chronic Norovirus diarrhea has been reported and appears promising, including in solid organ transplant recipients. However, the drug is not yet approved for this indication. We herein report on a patient for which nitazoxanide induced dose-dependent toxic agranulocytosis.
Citation	Grépilloux D, Guéneau C, Weinhard J, Richaud R, Chevallier E, Jouve T, Dusserre J, Rostaing L. Toxic agranulocytosis following nitazoxanide treatment for norovirus diarrhea in a kidney transplant recipient: A case report and review of literature. World J Transplant 2025; In press

Received	2025-02-21 03:39
Peer-Review Started	2025-02-21 03:39
To Make the First Decision
Return for Revision	2025-03-25 05:20
Revised	2025-04-24 07:20
Second Decision	2025-09-24 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-24 09:50
Articles in Press	2025-09-24 09:50
Publication Fee Transferred	2025-06-11 21:01
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ISSN	2220-3230 (online)
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