Publication Name	World Journal of Gastroenterology
Manuscript ID	106057
Country	China

Category	Medicine, General & Internal
Manuscript Type	Letter to the Editor
Article Title	Microbiota geography in the colorectal carcinoma microenvironment: A spatiotemporal atlas of colonic mucosal microbial niche reconstruction
Manuscript Source	Unsolicited Manuscript
All Author List	Zong-Qiang Han and Li-Na Wen
Funding Agency and Grant Number	Funding Agency Grant Number The Beijing High Level Public Health Technology Talent Construction Project backbone-03-04
Corresponding Author	Li-Na Wen, Associate Research Scientist, Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, No. 10 Tieyi Road, Yangfangdian Street, Haidian District, Beijing 100038, China. wenlina3074@bjsjth.cn
Key Words	Microbiota; Colorectal cancer; Colon mucosa; Geography; Case control study
Core Tip	A clinical study from a specific Indonesian population showed that the colonic mucosal microbial composition differs significantly between patients with and without colorectal cancer at the genus and species levels. The combination of Fusobacterium nucleatum and Bacteroides fragilis may serve as a diagnostic biomarker for colorectal cancer. The area under the curve for combined diagnosis was 0.786 (95% confidence interval: 0.671-0.900), with 82.8% sensitivity and 50% specificity. Although the study yielded significant reference results, it was relatively limited in sample size, disease staging, dietary factors, and functional studies of the differential microbiota. Future research should improve on these aspects.
Citation	Han ZQ, Wen LN. Microbiota geography in the colorectal carcinoma microenvironment: A spatiotemporal atlas of colonic mucosal microbial niche reconstruction. World J Gastroenterol 2025; In press

Received	2025-02-20 07:04
Peer-Review Started	2025-02-20 07:04
To Make the First Decision
Return for Revision	2025-03-18 19:54
Revised	2025-03-29 09:46
Second Decision	2025-04-18 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-18 05:34
Articles in Press	2025-04-18 05:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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