Publication Name	World Journal of Critical Care Medicine
Manuscript ID	106085
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Letter to the Editor
Article Title	Paradox of protection: Re-examining cannabis use disorder in sepsis outcomes among cancer patients
Manuscript Source	Invited Manuscript
All Author List	Wu-Si Qiu, Hao-Dong Chen, Wen-Jie Yang and Ming-Min Chen
Funding Agency and Grant Number	Funding Agency Grant Number the Scientific Research Fund of Hangzhou Health Department, China A20251639
Corresponding Author	Wu-Si Qiu, Associate Chief Physician, Associate Professor, MD, PhD, Department of Neurosurgery, Affiliated Hospital of Hangzhou Normal University, No. 126 Wenzhou Road, Gongshu District, Hangzhou 310015, Zhejiang Province, China. shihai954@163.com
Key Words	Cannabis/marijuana; Sepsis; Cannabis use disorder; Cardiovascular outcomes; Critical care; Cancer
Core Tip	This letter critiques a recent study revealing reduced sepsis mortality in cancer patients with cannabis use disorder. We highlight methodological limitations (e.g., coding bias and lack of dosage data) and propose future directions, including mechanistic studies on cannabinoid immunomodulation and policy reforms to address socioeconomic disparities. Key innovations include reconciling paradoxical findings through updated preclinical evidence, equitable policy frameworks to translate findings into clinical practice, and aligning policy recommendations with consensus and guidelines (e.g., National Comprehensive Cancer Network).
Citation	Qiu WS, Chen HD, Yang WJ, Chen MM. Paradox of protection: Re-examining cannabis use disorder in sepsis outcomes among cancer patients. World J Crit Care Med 2025; In press

Received	2025-02-17 08:42
Peer-Review Started	2025-02-17 08:43
To Make the First Decision
Return for Revision	2025-04-08 04:05
Revised	2025-04-16 15:16
Second Decision	2025-06-19 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-20 01:05
Articles in Press	2025-06-20 01:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3141(online)
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