Publication Name	World Journal of Hepatology
Manuscript ID	106151
Country	China

Category	Anatomy & Morphology
Manuscript Type	Basic Study
Article Title	Deciphering the oncogenic role of Rac family small GTPase 3 in hepatocellular carcinoma through multiomics integration
Manuscript Source	Unsolicited Manuscript
All Author List	Run Liu, Jin-Cheng Li, Shi-De Li, Jian-Di Li, Rong-Quan He, Gang Chen, Zhen-Bo Feng and Jia-Liang Wei
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82260581
Corresponding Author	Zhen-Bo Feng, MD, Professor, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. fengzhenbo_gxmu@163.com
Key Words	Rac family small GT Phase 3; Hepatocellular carcinoma; Immunohistochemistry; High-throughput sequencing; Clustered regularly interspaced short palindromic repeats screening
Core Tip	This study identifies Rac family small GTPase 3 (RAC3) as a critical oncogenic driver in hepatocellular carcinoma (HCC) through multi functional validation. RAC3 overexpression correlates with advanced tumor stage and poor prognosis (hazard ratio = 1.82), while clustered regularly interspaced short palindromic repeats screening confirms its necessity for HCC proliferation. Mechanistically, E2F transcription factor 1 transcriptionally activates RAC3, which drives cell-cycle dysregulation. These findings position RAC3 as a promising therapeutic target for combating chemotherapy resistance in HCC.
Citation	Liu R, Li JC, Li SD, Li JD, He RQ, Chen G, Feng ZB, Wei JL. Deciphering the oncogenic role of Rac family small GTPase 3 in hepatocellular carcinoma through multiomics integration. World J Hepatol 2025; In press

Received	2025-03-05 11:33
Peer-Review Started	2025-03-07 01:39
To Make the First Decision
Return for Revision	2025-04-16 10:45
Revised	2025-04-26 11:12
Second Decision	2025-06-11 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-11 08:40
Articles in Press	2025-06-11 08:40
Publication Fee Transferred	2025-04-30 02:56
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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