Publication Name	World Journal of Psychiatry
Manuscript ID	106164
Country	China

Category	Psychiatry
Manuscript Type	Meta-Analysis
Article Title	Meta-analysis of factors associated with the incidence of comorbid depression and anxiety in patients with chronic hepatitis B
Manuscript Source	Unsolicited Manuscript
All Author List	Li Guo, Li-Xia He, Pei-Qi Wan, Xiu-Mei Zhen, Fang Xiao, Wen-Bin Wu, Ming-Hua Su, Bi-Hua Gao and Zhi-Hong Liu
Funding Agency and Grant Number	Funding Agency Grant Number Beihai City Science and Technology Program Projects Beikehe 2023158020
Corresponding Author	Zhi-Hong Liu, Department of Infectious Diseases, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. liuzh308@163.com
Key Words	Chronic hepatitis B; Depression; Anxiety; Correlative factors; Meta-analysis
Core Tip	Patients with chronic hepatitis B may experience a significant burden of mental-health issues, with 30.1% experiencing depression, 40.2% anxiety, and 33.7% overall negative emotions. Higher educational level was a protective factor (odds ratio = 0.43) by enhancing self-management and disease understanding, whereas older age, longer treatment duration, comorbidities, poor sleep quality, emotional instability, frequent hepatitis relapses, and severe hepatitis status all elevated the risk of comorbid depression and anxiety. Clinically, early identification of high-risk groups and targeted interventions, such as education-based counseling and sleep management, are crucial for improving mental-health outcomes, although current research heterogeneity from diverse assessment tools and regional sampling indicates the need for standardized broader population studies in the future.
Citation	Guo L, He LX, Wan PQ, Zhen XM, Xiao F, Wu WB, Su MH, Gao BH, Liu ZH. Meta-analysis of factors associated with the incidence of comorbid depression and anxiety in patients with chronic hepatitis B. World J Psychiatry 2025; In press

Received	2025-05-28 08:54
Peer-Review Started	2025-05-28 08:54
To Make the First Decision
Return for Revision	2025-06-19 03:48
Revised	2025-07-14 14:52
Second Decision	2025-08-18 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-26 01:04
Articles in Press	2025-08-26 01:04
Publication Fee Transferred	2025-07-16 08:38
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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