Publication Name	World Journal of Gastroenterology
Manuscript ID	106166
Country	Slovakia

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Myeloperoxidase, extracellular DNA and neutrophil extracellular trap formation in the animal models of metabolic dysfunction-associated steatotic liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Andrej Feješ, Paulína Belvončíková, Emil Bečka, Tomáš Strečanský, Michal Pastorek, Jakub Janko, Barbora Filová, Pavel Babál, Katarína Šebeková, Veronika Borbélyová and Roman Gardlík
Funding Agency and Grant Number	Funding Agency Grant Number Slovak Research and Development Agency APVV-21-0370 Ministry of Education, Science, Research and Sport of the Slovak Republic VEGA 1/0706/25 and VEGA 1/0341/23
Corresponding Author	Roman Gardlík, Associate Professor, Head, MD, PhD, Institute of Molecular Biomedicine, Comenius University Faculty of Medicine, Sasinkova 4, Bratislava 81108, Slovakia. roman.gardlik@fmed.uniba.sk
Key Words	Cell-free DNA; Mouse models; Metabolic dysfunction-associated steatotic liver disease; Neutrophil extracellular traps; Steatohepatitis; Myeloperoxidase; Neutrophil elastase
Core Tip	Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health concern with limited therapeutic options. This study demonstrated that extracellular DNA (ecDNA) and neutrophil extracellular traps (NETs) serve as potential biomarkers of liver injury severity in MASLD. Using three distinct animal models, we showed that NET markers, including myeloperoxidase and ecDNA, correlated with liver fibrosis and inflammation. These findings highlighted NETs and ecDNA as promising targets for early diagnosis and intervention in MASLD, offering new insights into disease progression and potential therapeutic strategies.
Citation	Feješ A, Belvončíková P, Bečka E, Strečanský T, Pastorek M, Janko J, Filová B, Babál P, Šebeková K, Borbélyová V, Gardlík R. Myeloperoxidase, extracellular DNA and neutrophil extracellular trap formation in the animal models of metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2025; In press

Received	2025-02-25 03:43
Peer-Review Started	2025-02-25 03:43
To Make the First Decision
Return for Revision	2025-04-02 07:05
Revised	2025-06-12 06:35
Second Decision	2025-06-16 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-16 07:52
Articles in Press	2025-06-16 07:52
Publication Fee Transferred	2025-04-23 08:56
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com