| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Impact of non-alcoholic hepatic steatosis on prognosis and clinical outcomes in gastric cancer patients undergoing laparoscopic distal gastrectomy
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Fan Zou, Yi-Gang Zhang, Zi-Chu Zhao, Zheng Li, Hong-Da Liu, Qing-Ya Li, Ze-Tian Chen, Cheng-Jun Zhu, Hai-Tao Liu, Ji-Wei Wang, Feng-Yuan Li, Lin-Jun Wang, Dian-Cai Zhang, Li Yang, Hao Xu, Ze-Kuan Xu and Sen Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| China Postdoctoral Science Foundation |
2021TQ0132 |
| The Youth Fund Program for National Natural Science Foundation of China from the First Affiliated Hospital of Nanjing Medical University |
PY2021032 |
|
| Corresponding Author |
Sen Wang, MD, PhD, Gastric Cancer Center, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Gulou District, Nanjing 210029, Jiangsu Province, China. wangsen199206@qq.com |
| Key Words |
Non-alcoholic fatty liver disease; Gastric cancer; Laparoscopic distal gastrectomy; Prognosis; Metabolic dysregulation |
| Core Tip |
This is a retrospective single-center observational study to investigate the potential impacts of Non-alcoholic fatty liver disease (NAFLD) on gastric cancer (GC) patients receiving laparoscopic distal gastrectomy. Propensity score-matching analysis was utilized to generate a balanced cohort and we observed no difference in major clinicopathological characteristics between GC patients with and without NAFLD. Moreover, survival analysis indicated that GC patients with hepatic steatosis experience inferior progression-free survival (PFS) compared with those without NAFLD. In summary, NAFLD is a predictive factor of PFS and could be further employed in the clinical management of GC. |
| Citation |
Zou YF, Zhang YG, Zhao ZC, Li Z, Liu HD, Li QY, Chen ZT, Zhu CJ, Liu HT, Wang JW, Li FY, Wang LJ, Zhang DC, Yang L, Xu H, Xu ZK, Wang S. Impact of non-alcoholic hepatic steatosis on prognosis and clinical outcomes in gastric cancer patients undergoing laparoscopic distal gastrectomy. World J Gastrointest Surg 2025; In press |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
