Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	106238
Country	China

Category	Oncology
Manuscript Type	Review
Article Title	Advances in pancreatic cancer epigenetics: From the mechanism to the clinic
Manuscript Source	Unsolicited Manuscript
All Author List	Jia-Dan Zhou and Hong-Zhang Shen
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82304628 Natural Science Foundation of Zhejiang Province LQ23H160047
Corresponding Author	Hong-Zhang Shen, Adjunct Associate Professor, Associate Chief Physician, MD, PhD, Department of Gastroenterology, Hangzhou First People's Hospital, No. 256 Huansha Road, Shangcheng District, Hangzhou 310000, Zhejiang Province, China. shenhongzhang@zju.edu.cn
Key Words	Pancreatic cancer; Epigenetics; Diagnosis; Treatment; Prognosis
Core Tip	Pancreatic cancer (PC) is a highly malignant cancer that is difficult to diagnose early and is resistant to conventional treatments. Epigenetic modifications, including DNA methylation, histone modification, and noncoding RNA expression, regulate gene expression without altering DNA sequences and play key roles in tumor development and treatment responses. This review discusses the epigenetic mechanisms, early diagnosis, prognosis, and treatment strategies for PC. Epigenetics, combined with immunotherapies, offers new treatment possibilities, but challenges remain, including resistance and side effects. The integration of epigenetics and precision medicine holds great potential for improving PC treatment and outcomes.
Citation	Zhou JD, Shen HZ. Advances in pancreatic cancer epigenetics: From the mechanism to the clinic. World J Gastrointest Oncol 2025; In press

Received	2025-03-03 01:45
Peer-Review Started	2025-03-03 01:45
To Make the First Decision
Return for Revision	2025-04-08 15:19
Revised	2025-04-20 16:00
Second Decision	2025-06-03 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-03 07:59
Articles in Press	2025-06-03 07:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	Zhou JD, Shen HZ. Advances in pancreatic cancer epigenetics: From the mechanism to the clinic. World J Gastrointest Oncol 2025; In press
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com