Publication Name	World Journal of Stem Cells
Manuscript ID	106282
Country	China

Category	Orthopedics
Manuscript Type	Basic Study
Article Title	Bone marrow mesenchymal stem cell-derived exosomal lactate dehydrogenase A promotes tendon-bone healing via histone lactylation-mediated cartilage regeneration
Manuscript Source	Unsolicited Manuscript
All Author List	Ting Zhang, Qing Huang and Kai-Feng Gan
Funding Agency and Grant Number
Corresponding Author	Kai-Feng Gan, Department of Orthopedics, The Affiliated Lihuili Hospital of Ningbo University, No. 57 Xingning Road, Ningbo 315211, Zhejiang Province, China. gankaifeng@163.com
Key Words	Tendon-bone healing; Bone mesenchymal stromal cells; Exosome; Lactate dehydrogenase A; Histone lactylation modification; Cartilage fragments
Core Tip	This study reveals that lactate dehydrogenase A (LDHA) in exosomes from bone marrow mesenchymal stem cells significantly enhances tendon-bone healing after anterior cruciate ligament reconstruction. LDHA promotes chondrocyte stem cell proliferation and differentiation by increasing lactate secretion and upregulating bone morphogenetic protein 7 via histone H3K18 lactylation. High LDHA expression boosts cartilage and fibrocartilage regeneration, accelerates new bone formation, and reverses bone morphogenetic protein 7 knockdown effects. These findings highlight LDHA-rich exosomes from bone marrow mesenchymal stem cells as a promising therapeutic strategy for improving anterior cruciate ligament reconstruction outcomes.
Citation	Zhang T, Huang Q, Gan KF. Bone marrow mesenchymal stem cell-derived exosomal lactate dehydrogenase A promotes tendon-bone healing via histone lactylation-mediated cartilage regeneration. World J Stem Cells 2025; In press

Received	2025-02-26 08:10
Peer-Review Started	2025-03-04 00:06
To Make the First Decision
Return for Revision	2025-03-19 02:01
Revised	2025-03-27 10:40
Second Decision	2025-08-29 00:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-05 06:51
Articles in Press	2025-09-05 06:51
Publication Fee Transferred	2025-04-03 13:48
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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