| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Multi-omics analysis reveals gut microbiota-metabolite interactions and their association with liver function in autoimmune overlap syndrome
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qi Wang, Li-Na Sun, Han Shi, Xin-Yue Ma, Wen Gao, Bin Xu, Xiao Lin, Yan-Min Liu, Chun-Yang Huang and Rong-Hua Jin |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| WBE Liver Foundation |
No. WBE2022018 |
| 2022 Young and middle-aged Talents Incubation Project (Youth Innovation) of Beijing Youan Hospital, Capital Medical University |
No. BJYAYY-YN-2022-09 |
| 2023 Young and middle-aged Talents Incubation Project (Youth Innovation) of Beijing Youan Hospital, Capital Medical University |
No. BJYAYYYN2023-14 |
|
| Corresponding Author |
Rong-Hua Jin, Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang District, Beijing 100015, China. ronghuajin@ccmu.edu.cn |
| Key Words |
Overlap syndrome; Multi-omics; Gut microbiomes; Metabolites; Liver function |
| Core Tip |
This study characterizes the distinct gut microbiome and serum metabolite profiles in overlap syndrome (OS), a severe condition combining features of primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH). Using 16S rRNA sequencing and liquid chromatography-mass spectrometry metabolomics, we observed significant microbial dysbiosis in OS patients, featuring reduced diversity, decreased Firmicutes and Bacteroidetes, and increased Proteobacteria. Serum analysis detected unique metabolites including pentadecaonoic acid and aminoimidazole carboxamide ribonucleotide. Most importantly, multi-omics analysis revealed a novel association between elevated aspartate aminotransferase levels, depleted Fusicatenibacter bacteria, and reduced L-Tyrosine, suggesting their potential role in OS pathogenesis. These findings provide the first comprehensive evidence linking gut microbiota dysbiosis with specific metabolic alterations in OS, offering new insights into disease mechanisms and potential diagnostic biomarkers for distinguishing OS from PBC or AIH alone. The microbial-metabolite network discovered in this study may open new avenues for therapeutic interventions targeting the gut-liver axis in autoimmune liver diseases. |
| Citation |
Wang Q, Sun LN, Shi H, Ma XY, Gao W, Xu B, Lin X, Liu YM, Huang CY, Jin RH. Multi-omics analysis reveals gut microbiota-metabolite interactions and their association with liver function in autoimmune overlap syndrome. World J Gastroenterol 2025; In press |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
