Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	106412
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Endoscopic resection of colorectal laterally spreading tumors: Clinicopathologic characteristics and risk factors for treatment outcomes
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Hua Guo, Ke-Feng Hu, Min Miao, Yong Ding, Xin-Jun Zhang and Guo-Liang Ye
Funding Agency and Grant Number
Corresponding Author	Guo-Liang Ye, Full Professor, Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, No. 247 Renmin Road, Jiangbei District, Ningbo 315020, Zhejiang Province, China. ndfyygl@163.com
Key Words	Colorectal neoplasms; Laterally spreading tumor; Endoscopic morphology; Endoscopic submucosal dissection; Endoscopic mucosal resection; Submucosal invasion
Core Tip	We retrospectively analyzed 375 colorectal laterally spreading tumors (LSTs) at our hospital between January 2016 and December 2023. Univariate and multivariate analyses were performed to identify risk factors for high-grade dysplasia/carcinoma, submucosal invasion and complications. The novel nomogram incorporated tumor size, location, and morphology for predicting high-grade dysplasia/carcinoma during endoscopic resection for LSTs. Multivariate analysis indicated that LST non-granular pseudo depressed type lesions larger than 20 mm had a significantly higher probability of submucosal invasion. Additionally, tumor size ≥ 30 mm emerged as a critical predictor of complications.
Citation	Guo LH, Hu KF, Miao M, Ding Y, Zhang XJ, Ye GL. Endoscopic resection of colorectal laterally spreading tumors: Clinicopathologic characteristics and risk factors for treatment outcomes. World J Gastrointest Endos 2025; In press

Received	2025-03-07 14:07
Peer-Review Started	2025-03-18 09:07
To Make the First Decision
Return for Revision	2025-03-27 10:41
Revised	2025-04-09 07:32
Second Decision	2025-05-08 02:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-08 12:44
Articles in Press	2025-05-08 12:44
Publication Fee Transferred	2025-04-11 08:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5190 (online)
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