Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	106414
Country	China

Category	Infectious Diseases
Manuscript Type	Retrospective Study
Article Title	Association between hepatitis B virus markers and liver fibrosis staging in patients with chronic hepatitis B
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Jing Huang, Xiao Zheng and Kai Wang
Funding Agency and Grant Number
Corresponding Author	Xiao-Jing Huang, Department of Infection, Hangzhou Linping District First People’s Hospital, No. 369, Yingbin Road, Nanyuan Street, Linping District, Hangzhou 311100, Zhejiang Province, China. 13306521018@163.com
Key Words	Hepatitis B core antibody; Hepatitis B virus DNA; Hepatitis B surface antigen; Chronic hepatitis B; Liver fibrosis staging
Core Tip	By combining three serum biomarkers, hepatitis B core antibody, hepatitis B virus-DNA, and hepatitis B surface antigen, this study proposes a cost-effective, non-invasive diagnostic approach for assessing chronic hepatitis B-related liver fibrosis (LF) staging, providing advantages in operational convenience and repeatability. The multi-parameter model demonstrated superior diagnostic performance without compromising either sensitivity or specificity. Further, a strong correlation of hepatitis B core antibody and hepatitis B virus-DNA with LF progression was determined. Altogether, a promising non-invasive serological tool for LF staging is proposed in this study, providing a cost-effective solution to improve clinical diagnostics and patient care.
Citation	Huang XJ, Zheng X, Wang K. Association between hepatitis B virus markers and liver fibrosis staging in patients with chronic hepatitis B. World J Gastrointest Surg 2025; In press

Received	2025-05-16 09:19
Peer-Review Started	2025-05-16 09:20
To Make the First Decision
Return for Revision	2025-06-07 05:45
Revised	2025-06-17 05:49
Second Decision	2025-08-22 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-22 08:25
Articles in Press	2025-08-22 08:25
Publication Fee Transferred	2025-07-07 03:43
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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