Publication Name	World Journal of Gastroenterology
Manuscript ID	106440
Country	Uzbekistan

Category	Medicine, Research & Experimental
Manuscript Type	Letter to the Editor
Article Title	Redefining the treatment paradigm for esophageal gastrointestinal stromal tumors: The emerging role of endoscopic resection
Manuscript Source	Invited Manuscript
All Author List	Konstantin Semash and Timur Dzhanbekov
Funding Agency and Grant Number
Corresponding Author	Konstantin Semash, MD, PhD, Department of Mini-Invasive Surgery, National Children's Medical Center, Parkent Street 294, Tashkent 100171, Toshkent, Uzbekistan. doctorsemash@gmail.com
Key Words	Gastrointestinal stromal tumors; Esophageal neoplasms; Endoscopic resection; Minimally invasive surgical procedures; Treatment outcome; Survival
Core Tip	Endoscopic resection (ER) is emerging as a minimally invasive alternative to traditional surgery for esophageal gastrointestinal stromal tumors (GISTs), particularly for tumors ≤ 4 cm with low mitotic activity. The study by Xu et al provides compelling evidence supporting ER’s high En bloc resection rate and favorable long-term outcomes. However, critical questions remain regarding patient selection criteria, the oncologic safety of R1 resections, and the role of adjuvant therapy. Further prospective studies are needed to define ER’s place in the treatment algorithm and optimize management strategies for esophageal GISTs.
Citation	Semash K, Dzhanbekov T. Redefining the treatment paradigm for esophageal gastrointestinal stromal tumors: The emerging role of endoscopic resection. World J Gastroenterol 2025; In press

Received	2025-02-26 09:04
Peer-Review Started	2025-02-26 09:04
To Make the First Decision
Return for Revision	2025-04-12 06:20
Revised	2025-04-12 12:58
Second Decision	2025-06-05 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-05 06:57
Articles in Press	2025-06-05 06:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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