Publication Name	World Journal of Transplantation
Manuscript ID	106444
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Outcomes and complications of combined heart-liver transplantation in patients with failing Fontan physiology: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Muhammad Shahzil, Ume Habiba, Mariyah Zainab Irfan, Muhammad Ahmad Qureshi, Muhammad Saad Faisal, Talha Kashif, Ali Akram Qureshi, Hassam Ali, Vinay Jahagirdar and Rakesh Vinayek
Funding Agency and Grant Number
Corresponding Author	Hassam Ali, MD, Division of Gastroenterology, Hepatology and Nutrition, East Carolina University/Brody School of Medicine, 2100 statonsburg rg, Greenville, North Carolina 27858, United States. hassamali155@gmail.com
Key Words	Fontan procedure; Heart defects; Congenital; Heart transplantation; Liver transplantation; Multi-organ failure
Core Tip	This systematic review analyzes outcomes and complications associated with combined heart-liver transplantation (CHLT) in patients with failing Fontan physiology, a condition resulting from single-ventricle congenital heart disease palliated by the Fontan procedure. CHLT demonstrates a survival advantage over isolated heart transplantation, with significantly lower mortality and shorter ischemic times, while maintaining comparable perioperative outcomes. The findings emphasize the importance of multidisciplinary care, careful patient selection, and surgical expertise. Future prospective studies are needed to refine selection criteria and improve long-term survival in this high-risk population.
Citation	Shahzil M, Habiba U, Irfan MZ, Qureshi MA, Faisal MS, Kashif T, Qureshi AA, Hassam Ali, Jahagirdar V, Vinayek R. Outcomes and complications of combined heart-liver transplantation in patients with failing Fontan physiology: A systematic review. World J Transplant 2025; In press

Received	2025-02-28 13:04
Peer-Review Started	2025-02-28 13:04
To Make the First Decision
Return for Revision	2025-03-20 07:24
Revised	2025-03-30 15:44
Second Decision	2025-04-18 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-18 07:47
Articles in Press	2025-04-18 07:47
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ISSN	2220-3230 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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