Publication Name	World Journal of Stem Cells
Manuscript ID	106579
Country	China

Category	Hematology
Manuscript Type	Observational Study
Article Title	Recombinant human thrombopoietin safety and efficacy in pediatric allogeneic hematopoietic stem cell transplantation: A cohort study
Manuscript Source	Unsolicited Manuscript
All Author List	Xue-Guo Li, Ru-Min Wang, Wei Chen, Tong Yao, Fen Chen, Yan-Fang Xu and Tao Lang
Funding Agency and Grant Number
Corresponding Author	Tao Lang, Chief Physician, MD, Department of Hematology, The People’s Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Urumqi 830001, Xinjiang Uygur Autonomous Region, China. langt2024@163.com
Key Words	Recombinant human thrombopoietin; Pediatric hematologic disorders; Allogeneic hematopoietic stem cell transplantation; Platelet engraftment; Graft-versus-host disease
Core Tip	This study evaluates the safety and efficacy of recombinant human thrombopoietin (rhTPO) in pediatric patients (0-17 years) undergoing allogeneic hematopoietic stem cell transplantation. Results show that rhTPO is well-tolerated and improves platelet recovery, with shorter platelet engraftment times in children (0-9 years) compared to adolescents (10-17 years). The incidence of acute graft-versus-host disease was higher in children but less severe. No severe adverse events related to rhTPO were observed, supporting its safety and utility in pediatric allogeneic hematopoietic stem cell transplantation. This study provides foundational insights for further research in larger pediatric cohorts.
Citation	Li XG, Wang RM, Chen W, Yao T, Chen F, Xu YF, Lang T. Recombinant human thrombopoietin safety and efficacy in pediatric allogeneic hematopoietic stem cell transplantation: A cohort study. World J Stem Cells 2025; In press

Received	2025-03-07 08:00
Peer-Review Started	2025-03-11 08:20
To Make the First Decision
Return for Revision	2025-04-07 12:24
Revised	2025-04-15 14:41
Second Decision	2025-06-18 05:27
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-25 07:44
Articles in Press	2025-06-25 07:44
Publication Fee Transferred	2025-04-19 01:04
Edit the Manuscript by Language Editor	2025-06-28 20:12
Typeset the Manuscript

ISSN	1948-0210 (online)
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