Publication Name	World Journal of Hepatology
Manuscript ID	106618
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Acute liver failure from anti-tuberculosis drug-induced liver injury: An update
Manuscript Source	Invited Manuscript
All Author List	Ramesh Kumar, Abhishek Kumar and Sudhir Kumar
Funding Agency and Grant Number
Corresponding Author	Ramesh Kumar, MD, Department of Gastroenterology, All India Institute of Medical Sciences, Phulwari Sharif, Patna 801507, India. docrameshkr@gmail.com
Key Words	Tuberculosis; Anti-tuberculosis drugs; Hepatotoxicity; Drug-induced liver injury; Acute liver failure
Core Tip	Tuberculosis (TB) remains a significant public health concern in developing countries. First-line anti-TB drugs (ATDs) pose a risk of drug-induced liver injury (DILI), which can progress to acute liver failure (ALF), a life-threatening condition. The global incidence of ATD-induced DILI is approximately 11.5%, with around 7% of cases progressing to ALF within two months of treatment initiation. Notably, young female patients are disproportionately affected by this condition, which is clinically indistinguishable from other causes of ALF and is associated with a high mortality rate, necessitating emergency liver transplantation. This minireview provides a comprehensive overview of ATD-induced ALF, covering epidemiology, risk factors, and treatment options.
Citation	Kumar R, Kumar A, Kumar S. Acute liver failure from anti-tuberculosis drug-induced liver injury: An update. World J Hepatol 2025; In press

Received	2025-03-04 12:41
Peer-Review Started	2025-03-14 00:14
To Make the First Decision
Return for Revision	2025-03-24 10:21
Revised	2025-04-01 15:56
Second Decision	2025-05-09 02:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-10 01:42
Articles in Press	2025-05-10 01:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com